{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Moeini Z"],"pubmed_abstract":["<b>Background:</b> The aggregation of tau and α-synuclein into fibrillary assemblies in nerve cells is the molecular hallmark of Alzheimer's and Parkinson's diseases, respectively. In our previous studies, we investigated the anti-amyloidogenic effects of three different aroma-producing (volatile) compounds including cinnamaldehyde, phenyl ethyl alcohol, and TEMED on the fibrillation process of HEWL, as a model protein. Our previous results showed that while TEMED was able to completely stop the process of fibril formation, cinnamaldehyde and phenyl ethyl alcohol gave rise to oligomeric/protofibrillar forms and were involved in the entrapment of intermediate species of HEWL. In this study, we investigated the anti-amyloidogenic effect of the same three volatile compounds on recombinantly p"],"journal":["Frontiers in pharmacology"],"pagination":["793727"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8980687"],"repository":["biostudies-literature"],"pubmed_title":["Unravelling the Novel Effects of Three Volatile Compounds in Preventing Fibril Formation of Disease Related Tau and α-Synuclein Proteins- Towards Identifying Candidate Aromatic Substances for Treating Neurodegenerative Diseases."],"pmcid":["PMC8980687"],"pubmed_authors":["Ashrafi-Kooshk M","Seraj Z","Saboury AA","Moeini Z","Zohoorian Abootorabi T","Seyedarabi A","Riazi G"],"additional_accession":[]},"is_claimable":false,"name":"Unravelling the Novel Effects of Three Volatile Compounds in Preventing Fibril Formation of Disease Related Tau and α-Synuclein Proteins- Towards Identifying Candidate Aromatic Substances for Treating Neurodegenerative Diseases.","description":"<b>Background:</b> The aggregation of tau and α-synuclein into fibrillary assemblies in nerve cells is the molecular hallmark of Alzheimer's and Parkinson's diseases, respectively. In our previous studies, we investigated the anti-amyloidogenic effects of three different aroma-producing (volatile) compounds including cinnamaldehyde, phenyl ethyl alcohol, and TEMED on the fibrillation process of HEWL, as a model protein. Our previous results showed that while TEMED was able to completely stop the process of fibril formation, cinnamaldehyde and phenyl ethyl alcohol gave rise to oligomeric/protofibrillar forms and were involved in the entrapment of intermediate species of HEWL. In this study, we investigated the anti-amyloidogenic effect of the same three volatile compounds on recombinantly p","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T09:51:42.572Z","creation":"2024-11-09T07:53:38.552Z"},"accession":"S-EPMC8980687","cross_references":{"pubmed":["35392564"],"doi":["10.3389/fphar.2022.793727"]}}