{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kundu S"],"funding":["National Institute of Allergy and Infectious Diseases"],"pagination":["810834"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8980737"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Leptospirosis is an emerging infectious disease. Recently, canine and human leptospirosis outbreaks were reported in California and New York, respectively. In this study we evaluated the role that cell death processes play in the inflammatory response to <i>Leptospira</i>. Groups of male C3H/HeJ mice were infected with pathogenic <i>L. interrogans</i> and non-pathogenic <i>L. biflexa</i> for 24 and 72 hours; inflammatory processes were characterized for apoptosis and necroptosis by flowcytometry of spleen cells and were further assessed for expression of biomarkers of necroptosis by western blot. We found that pathogenic <i>L. interrogans</i> promotes apoptosis in myeloid neutrophils and monocytes at 24h and 72h post-infection, whereas <i>L. biflexa</i> promotes apoptosis of myeloid monocy"],"journal":["Frontiers in immunology"],"pubmed_title":["Necroptosis Contributes to Persistent Inflammation During Acute Leptospirosis."],"pmcid":["PMC8980737"],"funding_grant_id":["AI142129, AI155211"],"pubmed_authors":["Gomes-Solecki M","Shetty A","Kundu S"],"additional_accession":[]},"is_claimable":false,"name":"Necroptosis Contributes to Persistent Inflammation During Acute Leptospirosis.","description":"Leptospirosis is an emerging infectious disease. Recently, canine and human leptospirosis outbreaks were reported in California and New York, respectively. In this study we evaluated the role that cell death processes play in the inflammatory response to <i>Leptospira</i>. Groups of male C3H/HeJ mice were infected with pathogenic <i>L. interrogans</i> and non-pathogenic <i>L. biflexa</i> for 24 and 72 hours; inflammatory processes were characterized for apoptosis and necroptosis by flowcytometry of spleen cells and were further assessed for expression of biomarkers of necroptosis by western blot. We found that pathogenic <i>L. interrogans</i> promotes apoptosis in myeloid neutrophils and monocytes at 24h and 72h post-infection, whereas <i>L. biflexa</i> promotes apoptosis of myeloid monocy","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T12:54:29.099Z","creation":"2025-04-19T12:54:29.099Z"},"accession":"S-EPMC8980737","cross_references":{"pubmed":["35392072"],"doi":["10.3389/fimmu.2022.810834"]}}