biostudies-literatureUnknown10Huang WThe rational design and construction of high-performance flexible electrochemical sensors based on hierarchical nanostructure functionalized microelectrode systems are of vital importance for sensitive <i>in situ</i> and real-time detection of biomolecules released from living cells. Herein, we report a novel and facile strategy to synthesize a new kind of high-performance microelectrode functionalized by dual nanozyme composed of rime-like Cu₂(OH)₃NO₃ wrapped ZnO nanorods assembly [Cu₂(OH)₃NO₃@ZnO], and explore its practical application in electrochemical detection of hydrogen peroxide (H₂O₂) released from living cells. Benefiting from the merits of the unique hierarchical nanohybrid structure and highFrontiers in chemistry873187https://www.ebi.ac.uk/biostudies/studies/S-EPMC8980740biostudies-literatureFunctionalized Graphene Fiber Modified With MOF-Derived Rime-Like Hierarchical Nanozyme for Electrochemical Biosensing of H₂O₂ in Cancer Cells.PMC8980740Huang WSun YXu YfalseFunctionalized Graphene Fiber Modified With MOF-Derived Rime-Like Hierarchical Nanozyme for Electrochemical Biosensing of H₂O₂ in Cancer Cells.The rational design and construction of high-performance flexible electrochemical sensors based on hierarchical nanostructure functionalized microelectrode systems are of vital importance for sensitive <i>in situ</i> and real-time detection of biomolecules released from living cells. Herein, we report a novel and facile strategy to synthesize a new kind of high-performance microelectrode functionalized by dual nanozyme composed of rime-like Cu₂(OH)₃NO₃ wrapped ZnO nanorods assembly [Cu₂(OH)₃NO₃@ZnO], and explore its practical application in electrochemical detection of hydrogen peroxide (H₂O₂) released from living cells. Benefiting from the merits of the unique hierarchical nanohybrid structure and high2022-01-01T00:00:00Z20222025-04-26T15:18:14.071Z2025-04-06T14:50:52.293ZS-EPMC89807403539242110.3389/fchem.2022.873187