{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hung AM"],"funding":["NHGRI NIH HHS","CSRD VA"],"pagination":["386-395"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8980930"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["182(4)"],"pubmed_abstract":["<h4>Importance</h4>Coronavirus disease 2019 (COVID-19) confers significant risk of acute kidney injury (AKI). Patients with COVID-19 with AKI have high mortality rates.<h4>Objective</h4>Individuals with African ancestry with 2 copies of apolipoprotein L1 (APOL1) variants G1 or G2 (high-risk group) have significantly increased rates of kidney disease. We tested the hypothesis that the APOL1 high-risk group is associated with a higher-risk of COVID-19-associated AKI and death.<h4>Design, setting, and participants</h4>This retrospective cohort study included 990 participants with African ancestry enrolled in the Million Veteran Program who were hospitalized with COVID-19 between March 2020 and January 2021 with available genetic information.<h4>Exposures</h4>The primary exposure was having 2 "],"journal":["JAMA internal medicine"],"pubmed_title":["APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program."],"pmcid":["PMC8980930"],"funding_grant_id":["R01 HG006139","I01 CX001897","IK2 CX002027"],"pubmed_authors":["Wilson P","Gappy S","Wilson O","Jhala D","Chen HC","Chang KM","Robinson-Cohen C","Gutierrez S","Kinlay S","Liang P","Aguayo S","Wendt F","Norton J","Godschalk M","Palacio A","Moser J","Dellitalia L","Okusaga O","Xu J","Shah SC","Ahuja S","Gaddy M","Huq M","Polimanti R","Moorman J","Ratcliffe N","Ballas Z","Akwo E","Hung AM","Huffman JE","Robey B","Whooley M","Harley J","Reaven P","Lichy J","Liangpunsakul S","Luoh SW","Hammer K","Stapley T","Liao K","Huffman J","Tandon N","Yu Z","Hunt CM","Mathew R","Zhou J","Servatius R","Gupta S","Balasubramanian P","Klein J","Sriram P","Greco J","Oursler K","Ramoni R","Murdoch M","Assimes T","Cohen D","Siew ED","Greevy RA","Ho YL","Beckham J","Wells J","Boyko E","Hauger R","Villareal G","Roussos P","Constans J","Tsao PS","Sharma S","Mastorides S","Casas JP","Damrauer S","Garcon H","Sun Y","Wallbom A","Meyer P","Suzuki A","Tuteja S","Jacono F","Fujii D","Matheny ME","Susztak K","Hung A","Whittle J","Muralidhar S","Alexander K","Pyarajan S","VA Million Veteran Program COVID-19 Science Initiative","Cho K","Fayad J","Hamner M","Kosik N","O'Donnell CJ","Iyengar S","Walsh J","Strollo P","Striker R","Rauchman M","Joseph J","McArdle R","Mattocks K","Smith R","Morgan T","Bhushan S","Tao R","Yeh S","Bick AG","Gaziano JM","Chung CP"],"additional_accession":[]},"is_claimable":false,"name":"APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program.","description":"<h4>Importance</h4>Coronavirus disease 2019 (COVID-19) confers significant risk of acute kidney injury (AKI). Patients with COVID-19 with AKI have high mortality rates.<h4>Objective</h4>Individuals with African ancestry with 2 copies of apolipoprotein L1 (APOL1) variants G1 or G2 (high-risk group) have significantly increased rates of kidney disease. We tested the hypothesis that the APOL1 high-risk group is associated with a higher-risk of COVID-19-associated AKI and death.<h4>Design, setting, and participants</h4>This retrospective cohort study included 990 participants with African ancestry enrolled in the Million Veteran Program who were hospitalized with COVID-19 between March 2020 and January 2021 with available genetic information.<h4>Exposures</h4>The primary exposure was having 2 ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T20:35:01.912Z","creation":"2025-04-04T20:35:01.912Z"},"accession":"S-EPMC8980930","cross_references":{"pubmed":["35089317"],"doi":["10.1001/jamainternmed.2021.8538"]}}