biostudies-literatureHung AMNHGRI NIH HHSCSRD VA386-395https://www.ebi.ac.uk/biostudies/studies/S-EPMC8980930biostudies-literatureUnknown182(4)<h4>Importance</h4>Coronavirus disease 2019 (COVID-19) confers significant risk of acute kidney injury (AKI). Patients with COVID-19 with AKI have high mortality rates.<h4>Objective</h4>Individuals with African ancestry with 2 copies of apolipoprotein L1 (APOL1) variants G1 or G2 (high-risk group) have significantly increased rates of kidney disease. We tested the hypothesis that the APOL1 high-risk group is associated with a higher-risk of COVID-19-associated AKI and death.<h4>Design, setting, and participants</h4>This retrospective cohort study included 990 participants with African ancestry enrolled in the Million Veteran Program who were hospitalized with COVID-19 between March 2020 and January 2021 with available genetic information.<h4>Exposures</h4>The primary exposure was having 2 JAMA internal medicineAPOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program.PMC8980930R01 HG006139I01 CX001897IK2 CX002027Wilson PGappy SWilson OJhala DChen HCChang KMRobinson-Cohen CGutierrez SKinlay SLiang PAguayo SWendt FNorton JGodschalk MPalacio AMoser JDellitalia LOkusaga OXu JShah SCAhuja SGaddy MHuq MPolimanti RMoorman JRatcliffe NBallas ZAkwo EHung AMHuffman JERobey BWhooley MHarley JReaven PLichy JLiangpunsakul SLuoh SWHammer KStapley TLiao KHuffman JTandon NYu ZHunt CMMathew RZhou JServatius RGupta SBalasubramanian PKlein JSriram PGreco JOursler KRamoni RMurdoch MAssimes TCohen DSiew EDGreevy RAHo YLBeckham JWells JBoyko EHauger RVillareal GRoussos PConstans JTsao PSSharma SMastorides SCasas JPDamrauer SGarcon HSun YWallbom AMeyer PSuzuki ATuteja SJacono FFujii DMatheny MESusztak KHung AWhittle JMuralidhar SAlexander KPyarajan SVA Million Veteran Program COVID-19 Science InitiativeCho KFayad JHamner MKosik NO'Donnell CJIyengar SWalsh JStrollo PStriker RRauchman MJoseph JMcArdle RMattocks KSmith RMorgan TBhushan STao RYeh SBick AGGaziano JMChung CPfalseAPOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program.<h4>Importance</h4>Coronavirus disease 2019 (COVID-19) confers significant risk of acute kidney injury (AKI). Patients with COVID-19 with AKI have high mortality rates.<h4>Objective</h4>Individuals with African ancestry with 2 copies of apolipoprotein L1 (APOL1) variants G1 or G2 (high-risk group) have significantly increased rates of kidney disease. We tested the hypothesis that the APOL1 high-risk group is associated with a higher-risk of COVID-19-associated AKI and death.<h4>Design, setting, and participants</h4>This retrospective cohort study included 990 participants with African ancestry enrolled in the Million Veteran Program who were hospitalized with COVID-19 between March 2020 and January 2021 with available genetic information.<h4>Exposures</h4>The primary exposure was having 2 2022-01-01T00:00:00Z2022 Apr2025-04-04T20:35:01.912Z2025-04-04T20:35:01.912ZS-EPMC89809303508931710.1001/jamainternmed.2021.8538