{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moreira CHV"],"funding":["NHLBI NIH HHS","NIMH NIH HHS","National Heart, Lung, and Blood Institute","NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III) International Component","National Institute of Mental Health","WHI NIH HHS"],"pagination":["104-112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8981372"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(2)"],"pubmed_abstract":["<h4>Background</h4>Acquisition of HIV primary drug resistant (PDR) infection can lead to poor virologic and clinical outcomes in individuals and hampers public health efforts in epidemic control. Monitoring PDR in HIV-positive blood donors can be used to inform nationwide trends in the spread of drug-resistant HIV strains.<h4>Methods</h4>We conducted a cross-sectional study using genetic sequence analysis to assess HIV pol sequences, PDR, and risk factors for infection using audio computer-assisted structured interviews in four large blood centers in Brazil from 2007 to 2017.<h4>Results</h4>Of 716 HIV-positive blood donors, 504 (70.4%) were successfully sequenced. HIV clade B (73.2%) was the most prevalent subtype, followed by a mix of non-B (21.2%) sub-types. A twofold increase (from 4% t"],"journal":["Transfusion medicine (Oxford, England)"],"pubmed_title":["HIV primary drug resistance and associated HIV risk factors among HIV positive blood donors in Brazil from 2007 to 2017."],"pmcid":["PMC8981372"],"funding_grant_id":["HHSN 268201100007I","R25 MH123256","HHSN268201100007C","HHSN268201100001I","R25 MH064712","HHSN 268201100001I","HHSN268201100007I","HHSN268201100001C"],"pubmed_authors":["Preiss L","Carneiro-Proietti AB","Salomon T","Teixeira CM","de Almeida-Neto C","Loureiro P","Lopes ME","Alencar CS","Goncalez TT","Mundim M","Custer B","Sabino EC","Moreira CHV"],"additional_accession":[]},"is_claimable":false,"name":"HIV primary drug resistance and associated HIV risk factors among HIV positive blood donors in Brazil from 2007 to 2017.","description":"<h4>Background</h4>Acquisition of HIV primary drug resistant (PDR) infection can lead to poor virologic and clinical outcomes in individuals and hampers public health efforts in epidemic control. Monitoring PDR in HIV-positive blood donors can be used to inform nationwide trends in the spread of drug-resistant HIV strains.<h4>Methods</h4>We conducted a cross-sectional study using genetic sequence analysis to assess HIV pol sequences, PDR, and risk factors for infection using audio computer-assisted structured interviews in four large blood centers in Brazil from 2007 to 2017.<h4>Results</h4>Of 716 HIV-positive blood donors, 504 (70.4%) were successfully sequenced. HIV clade B (73.2%) was the most prevalent subtype, followed by a mix of non-B (21.2%) sub-types. A twofold increase (from 4% t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-05-31T02:10:46.809Z","creation":"2025-04-04T23:04:12.088Z"},"accession":"S-EPMC8981372","cross_references":{"pubmed":["33665900"],"doi":["10.1111/tme.12766"]}}