biostudies-literatureMoreira CHVNHLBI NIH HHSNIMH NIH HHSNational Heart, Lung, and Blood InstituteNHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III) International ComponentNational Institute of Mental HealthWHI NIH HHS104-112https://www.ebi.ac.uk/biostudies/studies/S-EPMC8981372biostudies-literatureUnknown31(2)<h4>Background</h4>Acquisition of HIV primary drug resistant (PDR) infection can lead to poor virologic and clinical outcomes in individuals and hampers public health efforts in epidemic control. Monitoring PDR in HIV-positive blood donors can be used to inform nationwide trends in the spread of drug-resistant HIV strains.<h4>Methods</h4>We conducted a cross-sectional study using genetic sequence analysis to assess HIV pol sequences, PDR, and risk factors for infection using audio computer-assisted structured interviews in four large blood centers in Brazil from 2007 to 2017.<h4>Results</h4>Of 716 HIV-positive blood donors, 504 (70.4%) were successfully sequenced. HIV clade B (73.2%) was the most prevalent subtype, followed by a mix of non-B (21.2%) sub-types. A twofold increase (from 4% tTransfusion medicine (Oxford, England)HIV primary drug resistance and associated HIV risk factors among HIV positive blood donors in Brazil from 2007 to 2017.PMC8981372HHSN 268201100007IR25 MH123256HHSN268201100007CHHSN268201100001IR25 MH064712HHSN 268201100001IHHSN268201100007IHHSN268201100001CPreiss LCarneiro-Proietti ABSalomon TTeixeira CMde Almeida-Neto CLoureiro PLopes MEAlencar CSGoncalez TTMundim MCuster BSabino ECMoreira CHVfalseHIV primary drug resistance and associated HIV risk factors among HIV positive blood donors in Brazil from 2007 to 2017.<h4>Background</h4>Acquisition of HIV primary drug resistant (PDR) infection can lead to poor virologic and clinical outcomes in individuals and hampers public health efforts in epidemic control. Monitoring PDR in HIV-positive blood donors can be used to inform nationwide trends in the spread of drug-resistant HIV strains.<h4>Methods</h4>We conducted a cross-sectional study using genetic sequence analysis to assess HIV pol sequences, PDR, and risk factors for infection using audio computer-assisted structured interviews in four large blood centers in Brazil from 2007 to 2017.<h4>Results</h4>Of 716 HIV-positive blood donors, 504 (70.4%) were successfully sequenced. HIV clade B (73.2%) was the most prevalent subtype, followed by a mix of non-B (21.2%) sub-types. A twofold increase (from 4% t2021-01-01T00:00:00Z2021 Apr2026-05-31T02:10:46.809Z2025-04-04T23:04:12.088ZS-EPMC89813723366590010.1111/tme.12766