{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ike Y"],"funding":["Promotion of Science (JSPS) Grant-in-Aid for Scientific Research"],"pagination":["iyac025"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8982016"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["220(4)"],"pubmed_abstract":["The ubiquitin-proteasome system is associated with various phenomena including learning and memory. In this study, we report that E3 ubiquitin ligase homologs and proteasome function are involved in taste avoidance learning, a type of associative learning between starvation and salt concentrations, in Caenorhabditis elegans. Pharmacological inhibition of proteasome function using bortezomib causes severe defects in taste avoidance learning. Among 9 HECT-type ubiquitin ligase genes, loss-of-function mutations of 6 ubiquitin ligase genes cause significant abnormalities in taste avoidance learning. Double mutations of those genes cause lethality or enhanced defects in taste avoidance learning, suggesting that the HECT-type ubiquitin ligases act in multiple pathways in the processes of learning. Furthermore, mutations of the ubiquitin ligase genes cause additive effects on taste avoidance learning defects of the insulin-like signaling mutants. Our findings unveil the consequences of aberrant functions of the proteasome and ubiquitin systems in learning behavior of Caenorhabditis elegans."],"journal":["Genetics"],"pubmed_title":["Involvement of HECT-type E3 ubiquitin ligase genes in salt chemotaxis learning in Caenorhabditis elegans."],"pmcid":["PMC8982016"],"funding_grant_id":["JP17H06113"],"pubmed_authors":["Tomioka M","Iino Y","Ike Y"],"additional_accession":[]},"is_claimable":false,"name":"Involvement of HECT-type E3 ubiquitin ligase genes in salt chemotaxis learning in Caenorhabditis elegans.","description":"The ubiquitin-proteasome system is associated with various phenomena including learning and memory. In this study, we report that E3 ubiquitin ligase homologs and proteasome function are involved in taste avoidance learning, a type of associative learning between starvation and salt concentrations, in Caenorhabditis elegans. Pharmacological inhibition of proteasome function using bortezomib causes severe defects in taste avoidance learning. Among 9 HECT-type ubiquitin ligase genes, loss-of-function mutations of 6 ubiquitin ligase genes cause significant abnormalities in taste avoidance learning. Double mutations of those genes cause lethality or enhanced defects in taste avoidance learning, suggesting that the HECT-type ubiquitin ligases act in multiple pathways in the processes of learning. Furthermore, mutations of the ubiquitin ligase genes cause additive effects on taste avoidance learning defects of the insulin-like signaling mutants. Our findings unveil the consequences of aberrant functions of the proteasome and ubiquitin systems in learning behavior of Caenorhabditis elegans.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-20T03:03:06.39Z","creation":"2025-04-20T03:03:06.39Z"},"accession":"S-EPMC8982016","cross_references":{"pubmed":["35176147"],"doi":["10.1093/genetics/iyac025"]}}