biostudies-literatureDavis PMedical Research CouncilNHGRI NIH HHSNLM NIH HHSUS National Human Genome Research Instituteiyac003https://www.ebi.ac.uk/biostudies/studies/S-EPMC8982018biostudies-literatureUnknown220(4)WormBase (www.wormbase.org) is the central repository for the genetics and genomics of the nematode Caenorhabditis elegans. We provide the research community with data and tools to facilitate the use of C. elegans and related nematodes as model organisms for studying human health, development, and many aspects of fundamental biology. Throughout our 22-year history, we have continued to evolve to reflect progress and innovation in the science and technologies involved in the study of C. elegans. We strive to incorporate new data types and richer data sets, and to provide integrated displays and services that avail the knowledge generated by the published nematode genetics literature. Here, we provide a broad overview of the current state of WormBase in terms of data type, curation workflows, analysis, and tools, including exciting new advances for analysis of single-cell data, text mining and visualization, and the new community collaboration forum. Concurrently, we continue the integration and harmonization of infrastructure, processes, and tools with the Alliance of Genome Resources, of which WormBase is a founding member.GeneticsWormBase in 2022-data, processes, and tools for analyzing Caenorhabditis elegans.PMC8982018MR/S000453/1U24 HG010859U24 HG002223R01 LM013871Nuin PRodgers FHBecerra ARaciti DDiamantakis SHowe KLCain SWilliams GDavis PStein LSchindelman GYook KLuypaert MWang QCho JArnaboldi VHarris TWPaulini MQuinton-Tulloch MLee RYNWright AJChan JLe TSchedl TZarowiecki MSingh AVan Auken KGrigoriadis Dda Veiga Beltrame EStickland TNakamura CRussell MSternberg PWBerriman MGrove CAChen WJGao SMuller HMKishore RfalseWormBase in 2022-data, processes, and tools for analyzing Caenorhabditis elegans.WormBase (www.wormbase.org) is the central repository for the genetics and genomics of the nematode Caenorhabditis elegans. We provide the research community with data and tools to facilitate the use of C. elegans and related nematodes as model organisms for studying human health, development, and many aspects of fundamental biology. Throughout our 22-year history, we have continued to evolve to reflect progress and innovation in the science and technologies involved in the study of C. elegans. We strive to incorporate new data types and richer data sets, and to provide integrated displays and services that avail the knowledge generated by the published nematode genetics literature. Here, we provide a broad overview of the current state of WormBase in terms of data type, curation workflows, analysis, and tools, including exciting new advances for analysis of single-cell data, text mining and visualization, and the new community collaboration forum. Concurrently, we continue the integration and harmonization of infrastructure, processes, and tools with the Alliance of Genome Resources, of which WormBase is a founding member.2022-01-01T00:00:00Z2022 Apr2025-04-04T13:27:17.665Z2025-04-04T13:27:17.665ZS-EPMC89820183513492910.1093/genetics/iyac003