{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Weiner SG"],"funding":["Agency for Healthcare Research and Quality","NIDA NIH HHS","AHRQ HHS","National Institute on Drug Abuse"],"pagination":["e0266561"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8982846"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(4)"],"pubmed_abstract":["<h4>Background</h4>Hydrocodone and oxycodone are prescribed commonly to treat pain. However, differences in risk of opioid-related adverse outcomes after an initial prescription are unknown. This study aims to determine the risk of opioid-related adverse events, defined as either chronic use or opioid overdose, following a first prescription of hydrocodone or oxycodone to opioid naïve patients.<h4>Methods</h4>A retrospective analysis of multiple linked public health datasets in the state of Oregon. Adult patients ages 18 and older who a) received an initial prescription for oxycodone or hydrocodone between 2015-2017 and b) had no opioid prescriptions or opioid-related hospitalizations or emergency department visits in the year preceding the prescription were followed through the end of 201"],"journal":["PloS one"],"pubmed_title":["Opioid-related overdose and chronic use following an initial prescription of hydrocodone versus oxycodone."],"pmcid":["PMC8982846"],"funding_grant_id":["5-R01-HS026753","5-R01-DA044167","R01 HS026753","R01 DA044167"],"pubmed_authors":["El Ibrahimi S","Flores DP","Fischer MA","Hendricks MA","Hildebran C","Weiss RD","Boyer EW","Nelson LS","Ritter GA","Hallvik SE","Weiner SG","Kreiner PW"],"additional_accession":[]},"is_claimable":false,"name":"Opioid-related overdose and chronic use following an initial prescription of hydrocodone versus oxycodone.","description":"<h4>Background</h4>Hydrocodone and oxycodone are prescribed commonly to treat pain. However, differences in risk of opioid-related adverse outcomes after an initial prescription are unknown. This study aims to determine the risk of opioid-related adverse events, defined as either chronic use or opioid overdose, following a first prescription of hydrocodone or oxycodone to opioid naïve patients.<h4>Methods</h4>A retrospective analysis of multiple linked public health datasets in the state of Oregon. Adult patients ages 18 and older who a) received an initial prescription for oxycodone or hydrocodone between 2015-2017 and b) had no opioid prescriptions or opioid-related hospitalizations or emergency department visits in the year preceding the prescription were followed through the end of 201","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T15:59:11.782Z","creation":"2025-04-05T15:59:11.782Z"},"accession":"S-EPMC8982846","cross_references":{"pubmed":["35381052"],"doi":["10.1371/journal.pone.0266561"]}}