{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Xie X"],"pubmed_abstract":["Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss among the elderly worldwide with unidentified pathogenesis and limited therapeutic options. Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is central in the development and progression of AMD. Decorin (DCN), a small leucine-rich proteoglycan, possesses powerful antifibrotic, anti-inflammatory, and antiangiogenic properties. DCN has also been reported to serve a cytoprotective role in various cell types, but its protective effects against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress and apoptosis in ARPE-19 cells remain unclear. In this study, we showed that DCN significantly attenuated the increase in cell viability loss, apoptosis rate, and reactive oxygen species (ROS) "],"journal":["Oxidative medicine and cellular longevity"],"pagination":["3955748"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8983248"],"repository":["biostudies-literature"],"pubmed_title":["Decorin Protects Retinal Pigment Epithelium Cells from Oxidative Stress and Apoptosis via AMPK-mTOR-Regulated Autophagy."],"pmcid":["PMC8983248"],"pubmed_authors":["Xie T","Yao Y","Xie X","Li D","Cui Y","Cai J"],"additional_accession":[]},"is_claimable":false,"name":"Decorin Protects Retinal Pigment Epithelium Cells from Oxidative Stress and Apoptosis via AMPK-mTOR-Regulated Autophagy.","description":"Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss among the elderly worldwide with unidentified pathogenesis and limited therapeutic options. Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is central in the development and progression of AMD. Decorin (DCN), a small leucine-rich proteoglycan, possesses powerful antifibrotic, anti-inflammatory, and antiangiogenic properties. DCN has also been reported to serve a cytoprotective role in various cell types, but its protective effects against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress and apoptosis in ARPE-19 cells remain unclear. In this study, we showed that DCN significantly attenuated the increase in cell viability loss, apoptosis rate, and reactive oxygen species (ROS) ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T21:49:33.957Z","creation":"2025-04-19T21:49:33.957Z"},"accession":"S-EPMC8983248","cross_references":{"pubmed":["35391926"],"doi":["10.1155/2022/3955748"]}}