{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Van Simaeys D"],"funding":["NIDDK NIH HHS","JDRF","U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases"],"pagination":["1815"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8983715"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["The ability to detect and target β cells in vivo can substantially refine how diabetes is studied and treated. However, the lack of specific probes still hampers a precise characterization of human β cell mass and the delivery of therapeutics in clinical settings. Here, we report the identification of two RNA aptamers that specifically and selectively recognize mouse and human β cells. The putative targets of the two aptamers are transmembrane p24 trafficking protein 6 (TMED6) and clusterin (CLUS). When given systemically in immune deficient mice, these aptamers recognize the human islet graft producing a fluorescent signal proportional to the number of human islets transplanted. These aptamers cross-react with endogenous mouse β cells and allow monitoring the rejection of mouse islet allo"],"journal":["Nature communications"],"pubmed_title":["RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells."],"pmcid":["PMC8983715"],"funding_grant_id":["UC4 DK 116241","UC4 DK116241","SRA-2020-962-S-B","17-2013-326","2016-173-A-N"],"pubmed_authors":["Caroli J","Alcazar O","Zoso A","Serafini P","Bicciato S","Zilio S","Buchwald P","Grilli A","Kuznetsova V","De La Fuente A","Van Simaeys D"],"additional_accession":[]},"is_claimable":false,"name":"RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells.","description":"The ability to detect and target β cells in vivo can substantially refine how diabetes is studied and treated. However, the lack of specific probes still hampers a precise characterization of human β cell mass and the delivery of therapeutics in clinical settings. Here, we report the identification of two RNA aptamers that specifically and selectively recognize mouse and human β cells. The putative targets of the two aptamers are transmembrane p24 trafficking protein 6 (TMED6) and clusterin (CLUS). When given systemically in immune deficient mice, these aptamers recognize the human islet graft producing a fluorescent signal proportional to the number of human islets transplanted. These aptamers cross-react with endogenous mouse β cells and allow monitoring the rejection of mouse islet allo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-31T01:09:35.503Z","creation":"2025-04-03T22:51:26.489Z"},"accession":"S-EPMC8983715","cross_references":{"pubmed":["35383192"],"doi":["10.1038/s41467-022-29377-3"]}}