biostudies-literatureBecerril-Villanueva EConsejo Nacional de Ciencia y TecnologíaInstituto Nacional de Psiquiatría Ramón de la Fuente MuñizSecretaría de Ciencia, Tecnología e Innovación del Distrito Federal859768https://www.ebi.ac.uk/biostudies/studies/S-EPMC8983845biostudies-literatureUnknown13Airline pilots are frequently exposed to numerous flights per week, changes in their circadian rhythms, and extended periods away from home. All these stressors make pilots susceptible to developing psychiatric disorders. Recently, emphasis has been placed on the need for molecular tests that help in the diagnosis of depression. The genes <i>SLC6A4</i> and <i>S100A10</i> encode serotonin transporter (SERT) and p11 protein, respectively. Their expression has been frequently associated with stress and depression. In this work, we quantified, by quantitative PCR, the expression of SERT and p11 in peripheral mononuclear cells of airline pilots compared to patients with depression and healthy volunteers. Moreover, by mass spectrometry, we quantified the serum serotonin levels in the same three Frontiers in psychiatryScreening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach.PMC8983845NC150048SALUD-2017-1-289800NC16044.0INFRA-2015-01-252013SECITI 0048/2014Jose-Alfallo JALopez-Torres ASanchez-Garcia HOValencia Banos ARamirez-Marroquin OANogueira-Fernandez JMGonzalez-Ruiz OPerez-Sanchez GBecerril-Villanueva EMendoza-Contreras JMOlvera-Alvarez MIAlvarez-Herrera SPavon LMaldonado-Garcia JLJimenez-Genchi JTorres-Serrano ABMendieta-Cabrera DfalseScreening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach.Airline pilots are frequently exposed to numerous flights per week, changes in their circadian rhythms, and extended periods away from home. All these stressors make pilots susceptible to developing psychiatric disorders. Recently, emphasis has been placed on the need for molecular tests that help in the diagnosis of depression. The genes <i>SLC6A4</i> and <i>S100A10</i> encode serotonin transporter (SERT) and p11 protein, respectively. Their expression has been frequently associated with stress and depression. In this work, we quantified, by quantitative PCR, the expression of SERT and p11 in peripheral mononuclear cells of airline pilots compared to patients with depression and healthy volunteers. Moreover, by mass spectrometry, we quantified the serum serotonin levels in the same three 2022-01-01T00:00:00Z20222025-08-23T03:09:04.865Z2025-04-04T07:35:12.374ZS-EPMC89838453540125010.3389/fpsyt.2022.859768