{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Szczawinska-Poplonyk A"],"pubmed_abstract":["Infections and infectious complications are hallmarks of common variable immunodeficiency (CVID) and the leading cause of morbidity and mortality in affected patients at any age. However, the pediatric CVID is no longer perceived as a primary immunodeficiency associated solely with infectious manifestations; autoimmune, allergic, lymphoproliferative, and malignant disorders and organ-specific immunopathology also characterize the spectrum of non-infectious complications. In this study, we sought to determine the role of immune dysregulation and frequency of non-infectious sequelae in children affected with CVID. We also aimed at providing an insight into the pathogenesis of non-infectious complications and at delineating the diagnostic approach to pediatric CVID with immune dysregulation. "],"journal":["Frontiers in pediatrics"],"pagination":["855200"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8983883"],"repository":["biostudies-literature"],"pubmed_title":["Immune Dysregulation in Pediatric Common Variable Immunodeficiency: Implications for the Diagnostic Approach."],"pmcid":["PMC8983883"],"pubmed_authors":["Szczawinska-Poplonyk A","Ta Polska-Jozwiak K","Schwartzmann E","Poplonyk N"],"additional_accession":[]},"is_claimable":false,"name":"Immune Dysregulation in Pediatric Common Variable Immunodeficiency: Implications for the Diagnostic Approach.","description":"Infections and infectious complications are hallmarks of common variable immunodeficiency (CVID) and the leading cause of morbidity and mortality in affected patients at any age. However, the pediatric CVID is no longer perceived as a primary immunodeficiency associated solely with infectious manifestations; autoimmune, allergic, lymphoproliferative, and malignant disorders and organ-specific immunopathology also characterize the spectrum of non-infectious complications. In this study, we sought to determine the role of immune dysregulation and frequency of non-infectious sequelae in children affected with CVID. We also aimed at providing an insight into the pathogenesis of non-infectious complications and at delineating the diagnostic approach to pediatric CVID with immune dysregulation. ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-27T01:08:09.027Z","creation":"2025-04-06T18:07:02.104Z"},"accession":"S-EPMC8983883","cross_references":{"pubmed":["35402361"],"doi":["10.3389/fped.2022.855200"]}}