biostudies-literatureSnyder BMNCATS NIH HHSNIAID NIH HHSNHLBI NIH HHSNational Institutes of Health371-375https://www.ebi.ac.uk/biostudies/studies/S-EPMC8983891biostudies-literatureUnknown16(3)In this cohort study of hospitalized patients with linked medical record data, we developed International Classification of Diseases (ICD) criteria that accurately identified laboratory-confirmed, severe influenza hospitalizations (positive predictive value [PPV] 80%, 95% confidence interval [CI] 71-87%), which we validated through medical record documentation. These criteria identify patients with clinically important influenza illness outcomes to inform evaluation of preventive and therapeutic interventions and public health policy recommendations.Influenza and other respiratory virusesValidation of International Classification of Diseases criteria to identify severe influenza hospitalizations.PMC8983891R01 AI136526KL2 TR000446T32 HL087738KL2 TR000428Lee RLBraciale TJOrtiz JRSnyder BMGebretsadik THartert TVDing TWu PEdwards KMSomerville LAPatterson MFfalseValidation of International Classification of Diseases criteria to identify severe influenza hospitalizations.In this cohort study of hospitalized patients with linked medical record data, we developed International Classification of Diseases (ICD) criteria that accurately identified laboratory-confirmed, severe influenza hospitalizations (positive predictive value [PPV] 80%, 95% confidence interval [CI] 71-87%), which we validated through medical record documentation. These criteria identify patients with clinically important influenza illness outcomes to inform evaluation of preventive and therapeutic interventions and public health policy recommendations.2022-01-01T00:00:00Z2022 May2025-04-25T23:00:58.99Z2025-04-06T09:13:55.007ZS-EPMC89838913498483210.1111/irv.12931