biostudies-literatureUnknown7(3)Izumi M<h4>Purpose</h4>Altered pain facilitatory and inhibitory mechanisms have been recognized as an important manifestation in patients with chronic pain, and quantitative sensory testing (QST) can act as a proxy for this process. We have recently developed a simple bedside QST tool kit (<i>QuantiPain</i>) for more clinical use. The purpose of this study was to investigate its test-retest reliability and to evaluate its validity compared with the laboratory-based QST protocols in patients with knee osteoarthritis (OA).<h4>Methods</h4><i>QuantiPain</i> consists of 3 items: "pressure algometer" (for pressure pain thresholds [PPTs]), "pinprick" (for temporal summation of pain [TSP]), and "conditioning clamp" (for conditioned pain modulation [CPM]). In experiment-A, intrarater and interrater test-rPain reportse998https://www.ebi.ac.uk/biostudies/studies/S-EPMC8984378biostudies-literatureDetection of altered pain facilitatory and inhibitory mechanisms in patients with knee osteoarthritis by using a simple bedside tool kit (QuantiPain).PMC8984378Saito RHayashi YIzumi MOda SArendt-Nielsen LIkeuchi MPetersen KKfalseDetection of altered pain facilitatory and inhibitory mechanisms in patients with knee osteoarthritis by using a simple bedside tool kit (QuantiPain).<h4>Purpose</h4>Altered pain facilitatory and inhibitory mechanisms have been recognized as an important manifestation in patients with chronic pain, and quantitative sensory testing (QST) can act as a proxy for this process. We have recently developed a simple bedside QST tool kit (<i>QuantiPain</i>) for more clinical use. The purpose of this study was to investigate its test-retest reliability and to evaluate its validity compared with the laboratory-based QST protocols in patients with knee osteoarthritis (OA).<h4>Methods</h4><i>QuantiPain</i> consists of 3 items: "pressure algometer" (for pressure pain thresholds [PPTs]), "pinprick" (for temporal summation of pain [TSP]), and "conditioning clamp" (for conditioned pain modulation [CPM]). In experiment-A, intrarater and interrater test-r2022-01-01T00:00:00Z2022 May-Jun2025-05-18T12:06:35.984Z2025-05-18T12:06:35.984ZS-EPMC89843783539265110.1097/PR9.0000000000000998