biostudies-literatureUnknown12Wang QW<h4>Background</h4>Follow-up guidelines for serrated polyps (SPs) are mainly based on factors such as histology and size with limited evidence. The underlying genomic mechanism of SPs in relation to recurrence risks is utterly unknown.<h4>Methods</h4>We applied targeted next-generation sequencing (NGS) approach on two groups of SPs [polyp-relapsed SPs (PRSPs) vs. polyp-free SPs (PFSPs)] based on the surveillance outcomes to compare differences of DNA variants in 71 colorectal cancer-associated genes. A multicenter validation cohort was established longitudinally from 2016 to 2019 to confirm the relevant results.<h4>Results</h4>Among the 96 NGS samples, at least one mutant after filtration was detected in 90 samples (94%). Molecular profiling presented <i>BRAF</i>, <i>KRAS</i>, and <i>APC</Frontiers in oncology769709https://www.ebi.ac.uk/biostudies/studies/S-EPMC8984468biostudies-literature<i>ERBB2</i> Mutations as Potential Predictors for Recurrence in Colorectal Serrated Polyps by Targeted Next-Generation Sequencing.PMC8984468Wang QWLi XBWang RLZhou YJChen HTang ZRChen JNWang XYZhang QWfalse<i>ERBB2</i> Mutations as Potential Predictors for Recurrence in Colorectal Serrated Polyps by Targeted Next-Generation Sequencing.<h4>Background</h4>Follow-up guidelines for serrated polyps (SPs) are mainly based on factors such as histology and size with limited evidence. The underlying genomic mechanism of SPs in relation to recurrence risks is utterly unknown.<h4>Methods</h4>We applied targeted next-generation sequencing (NGS) approach on two groups of SPs [polyp-relapsed SPs (PRSPs) vs. polyp-free SPs (PFSPs)] based on the surveillance outcomes to compare differences of DNA variants in 71 colorectal cancer-associated genes. A multicenter validation cohort was established longitudinally from 2016 to 2019 to confirm the relevant results.<h4>Results</h4>Among the 96 NGS samples, at least one mutant after filtration was detected in 90 samples (94%). Molecular profiling presented <i>BRAF</i>, <i>KRAS</i>, and <i>APC</2022-01-01T00:00:00Z20222025-04-19T00:43:29.934Z2025-04-07T11:48:42.546ZS-EPMC89844683540221710.3389/fonc.2022.769709