{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(14)"],"submitter":["Ng JH"],"pubmed_abstract":["A practical three-component method for the synthesis of pyrazolo[3,4-<i>d</i>]pyrimidin-4-ones was developed. The reaction was performed in a one-pot manner under controlled microwave irradiation using easily accessible methyl 5-aminopyrazole-4-carboxylates, trimethyl orthoformate, and primary amines. Under the optimized conditions, challenging substrates, such as N-1 unsubstituted 5-aminopyrazole-4-carboxylates with another substituted amino group in position 3, reacted selectively affording 5-substituted 3-arylamino-1,5-dihydro-4<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-4-ones. The reaction tolerated a range of primary amines, including anilines. The advantages of the developed protocol include short reaction time, pot- and step-economy, and convenient chromatography-free product isolatio"],"journal":["RSC advances"],"pagination":["8323-8332"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8984946"],"repository":["biostudies-literature"],"pubmed_title":["Three-component microwave-assisted synthesis of 3,5-disubstituted pyrazolo[3,4-<i>d</i>]pyrimidin-4-ones."],"pmcid":["PMC8984946"],"pubmed_authors":["Dolzhenko AV","Tiekink ERT","Ng JH"],"additional_accession":[]},"is_claimable":false,"name":"Three-component microwave-assisted synthesis of 3,5-disubstituted pyrazolo[3,4-<i>d</i>]pyrimidin-4-ones.","description":"A practical three-component method for the synthesis of pyrazolo[3,4-<i>d</i>]pyrimidin-4-ones was developed. The reaction was performed in a one-pot manner under controlled microwave irradiation using easily accessible methyl 5-aminopyrazole-4-carboxylates, trimethyl orthoformate, and primary amines. Under the optimized conditions, challenging substrates, such as N-1 unsubstituted 5-aminopyrazole-4-carboxylates with another substituted amino group in position 3, reacted selectively affording 5-substituted 3-arylamino-1,5-dihydro-4<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-4-ones. The reaction tolerated a range of primary amines, including anilines. The advantages of the developed protocol include short reaction time, pot- and step-economy, and convenient chromatography-free product isolatio","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T09:10:01.063Z","creation":"2025-04-04T09:10:01.063Z"},"accession":"S-EPMC8984946","cross_references":{"pubmed":["35424837"],"doi":["10.1039/d2ra00980c"]}}