biostudies-literatureLi LYNational Natural Science Foundation of ChinaNatural Science Foundation of Jiangsu Province8443-8448https://www.ebi.ac.uk/biostudies/studies/S-EPMC8984952biostudies-literatureUnknown12(14)An atom-economic method of preparing allylic sulfones <i>via</i> hydrosulfonylation of allenes with sulfinic acids under Pd(0)-catalysis was reported. This process has a high degree of regio- and stereoselectivity, and provides the target product with a moderate to excellent yield. A wide range of nitrogen- or oxygen-containing linear <i>E</i>-allylic sulfones have been synthesized. With the support of experimental research, a possible mechanism was proposed.RSC advancesPalladium-catalyzed regioselective hydrosulfonylation of allenes with sulfinic acids.PMC898495221801130BK20180689Wei PLiu QQLi JZYu JWang DCLeng BRLi LYZhu YLfalsePalladium-catalyzed regioselective hydrosulfonylation of allenes with sulfinic acids.An atom-economic method of preparing allylic sulfones <i>via</i> hydrosulfonylation of allenes with sulfinic acids under Pd(0)-catalysis was reported. This process has a high degree of regio- and stereoselectivity, and provides the target product with a moderate to excellent yield. A wide range of nitrogen- or oxygen-containing linear <i>E</i>-allylic sulfones have been synthesized. With the support of experimental research, a possible mechanism was proposed.2022-01-01T00:00:00Z2022 Mar2025-04-04T07:35:01.227Z2025-04-04T07:35:01.227ZS-EPMC89849523542481810.1039/d1ra09036d