{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bohnen NI"],"funding":["NINDS NIH HHS","The Dunhill Medical Trust","Wellcome Trust","Academy of Medical Sciences","Parkinson's UK"],"pagination":["381-392"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8985079"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(4)"],"pubmed_abstract":["In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur in different brain regions. These changes correlate with a range of clinical features, both motor and non-motor, that are refractory to dopaminergic therapy, and can be conceptualised within a systems-level framework in which nodal deficits can produce circuit dysfunctions. The topographies of cholinergic changes overlap with neural circuitries involved in sleep and cognitive, motor, visuo-auditory perceptual, and autonomic functions. Cholinergic deficits within cognition network hubs predict cognitive deficits better than do total brain cholinergic changes. Postural instability and gait difficulties are associated with cholinergic system changes in thalamic, caudate, limbic, neocortical, and cerebella"],"journal":["The Lancet. Neurology"],"pubmed_title":["Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches."],"pmcid":["PMC8985079"],"funding_grant_id":["RPGF1906/154","G-1903","AMS-SGCL13-Weil","R21 NS114749","205167/Z/16/Z","P50 NS123067","R00 NS110878"],"pubmed_authors":["Weil RS","Borghammer P","Moro E","Bedard MA","Bohnen NI","Albin RL","Moehle MS","Yarnall AJ"],"additional_accession":[]},"is_claimable":false,"name":"Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches.","description":"In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur in different brain regions. These changes correlate with a range of clinical features, both motor and non-motor, that are refractory to dopaminergic therapy, and can be conceptualised within a systems-level framework in which nodal deficits can produce circuit dysfunctions. The topographies of cholinergic changes overlap with neural circuitries involved in sleep and cognitive, motor, visuo-auditory perceptual, and autonomic functions. Cholinergic deficits within cognition network hubs predict cognitive deficits better than do total brain cholinergic changes. Postural instability and gait difficulties are associated with cholinergic system changes in thalamic, caudate, limbic, neocortical, and cerebella","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-26T13:20:30.239Z","creation":"2025-04-06T14:09:44.463Z"},"accession":"S-EPMC8985079","cross_references":{"pubmed":["35131038"],"doi":["10.1016/S1474-4422(21)00377-X","10.1016/s1474-4422(21)00377-x"]}}