{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cui Y"],"funding":["Ministry of Science and Technology of the People&apos;s Republic of China","National Natural Science Foundation of China"],"pagination":["9519-9523"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8985103"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(16)"],"pubmed_abstract":["We report herein a highly efficient strategy for construction of a bridged oxa-[3.2.1]octane-embedded 5-7-6 tricyclic carbon skeleton through [3 + 2] IMCC (intramolecular [3 + 2] cross-cycloaddition), and the substituents and/or stereochemistries on C-4, C-6, C-7 and C-10 fully match those in the rhamnofolane, tigliane and daphnane diterpenoids. Furthermore, ring-opening of the bridged oxa-[3.2.1]octane <i>via</i> C-O bond cleavage was also successfully achieved."],"journal":["RSC advances"],"pubmed_title":["Highly efficient construction of an oxa-[3.2.1]octane-embedded 5-7-6 tricyclic carbon skeleton and ring-opening of the bridged ring <i>via</i> C-O bond cleavage."],"pmcid":["PMC8985103"],"funding_grant_id":["2021YFD1700103","21572103"],"pubmed_authors":["Lv J","Cui Y","Ren J","Song T","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Highly efficient construction of an oxa-[3.2.1]octane-embedded 5-7-6 tricyclic carbon skeleton and ring-opening of the bridged ring <i>via</i> C-O bond cleavage.","description":"We report herein a highly efficient strategy for construction of a bridged oxa-[3.2.1]octane-embedded 5-7-6 tricyclic carbon skeleton through [3 + 2] IMCC (intramolecular [3 + 2] cross-cycloaddition), and the substituents and/or stereochemistries on C-4, C-6, C-7 and C-10 fully match those in the rhamnofolane, tigliane and daphnane diterpenoids. Furthermore, ring-opening of the bridged oxa-[3.2.1]octane <i>via</i> C-O bond cleavage was also successfully achieved.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T23:16:35.21Z","creation":"2025-04-04T23:16:35.21Z"},"accession":"S-EPMC8985103","cross_references":{"pubmed":["35424922"],"doi":["10.1039/d2ra01315k"]}}