{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Plenderleith LJ"],"funding":["NIAID NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health"],"pagination":["1868"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8987028"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["The human parasite Plasmodium malariae has relatives infecting African apes (Plasmodium rodhaini) and New World monkeys (Plasmodium brasilianum), but its origins remain unknown. Using a novel approach to characterise P. malariae-related sequences in wild and captive African apes, we found that this group comprises three distinct lineages, one of which represents a previously unknown, highly divergent species infecting chimpanzees, bonobos and gorillas across central Africa. A second ape-derived lineage is much more closely related to the third, human-infective lineage P. malariae, but exhibits little evidence of genetic exchange with it, and so likely represents a separate species. Moreover, the levels and nature of genetic polymorphisms in P. malariae indicate that it resulted from the zo"],"journal":["Nature communications"],"pubmed_title":["Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes."],"pmcid":["PMC8987028"],"funding_grant_id":["R01 AI120810","R01 AI050529","P30 AI045008","R01 AI091595"],"pubmed_authors":["Sanz CM","Plenderleith LJ","Ulrich M","Mollison E","Esteban A","Peeters M","Leendertz FH","Calvignac-Spencer S","Liu W","Loy DE","Morgan DB","Shaw GM","Li Y","Wolfe ND","Connell J","Hahn BH","Ayouba A","Sharp PM","Sachse A"],"additional_accession":[]},"is_claimable":false,"name":"Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes.","description":"The human parasite Plasmodium malariae has relatives infecting African apes (Plasmodium rodhaini) and New World monkeys (Plasmodium brasilianum), but its origins remain unknown. Using a novel approach to characterise P. malariae-related sequences in wild and captive African apes, we found that this group comprises three distinct lineages, one of which represents a previously unknown, highly divergent species infecting chimpanzees, bonobos and gorillas across central Africa. A second ape-derived lineage is much more closely related to the third, human-infective lineage P. malariae, but exhibits little evidence of genetic exchange with it, and so likely represents a separate species. Moreover, the levels and nature of genetic polymorphisms in P. malariae indicate that it resulted from the zo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-06-01T12:11:31.377Z","creation":"2025-06-01T12:11:31.377Z"},"accession":"S-EPMC8987028","cross_references":{"pubmed":["35387986"],"doi":["10.1038/s41467-022-29306-4"]}}