{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Zhang J"],"funding":["Science and Technology Planning Project of Guangdong Province","National Natural Science Foundation of China"],"pubmed_abstract":["Integrin alpha L (ITGAL) is a member of the integrin family in which the abnormal expression is linked with carcinogenesis and immune regulation. However, the relation between ITGAL and the prognosis of gastric cancer (GC) and tumor-infiltrating lymphocytes (TILs) are not well understood. The differential expressions of ITGAL in human tumors and the clinical prognosis in GC were systematically analyzed <i>via</i> multiple databases including Gene Expression Profiling Interaction Analysis (GEPIA), UALCAN, Tumor Immune Estimation Resource (TIMER), and Kaplan-Meier (KM) plotter. TIMER, GEPIA, and TISIDB databases were used to comprehensively investigate the correlation between ITGAL and tumor infiltration immune cells. Also, further results were investigated by immunohistochemistry, qRT-PCR, "],"journal":["Frontiers in cell and developmental biology"],"pagination":["808212"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8987306"],"repository":["biostudies-literature"],"pubmed_title":["ITGAL as a Prognostic Biomarker Correlated With Immune Infiltrates in Gastric Cancer."],"pmcid":["PMC8987306"],"pubmed_authors":["Yuan C","Wu J","He Y","Zhang J","Wang H","Chen S","Zhang C","Xu J"],"additional_accession":[]},"is_claimable":false,"name":"ITGAL as a Prognostic Biomarker Correlated With Immune Infiltrates in Gastric Cancer.","description":"Integrin alpha L (ITGAL) is a member of the integrin family in which the abnormal expression is linked with carcinogenesis and immune regulation. However, the relation between ITGAL and the prognosis of gastric cancer (GC) and tumor-infiltrating lymphocytes (TILs) are not well understood. The differential expressions of ITGAL in human tumors and the clinical prognosis in GC were systematically analyzed <i>via</i> multiple databases including Gene Expression Profiling Interaction Analysis (GEPIA), UALCAN, Tumor Immune Estimation Resource (TIMER), and Kaplan-Meier (KM) plotter. TIMER, GEPIA, and TISIDB databases were used to comprehensively investigate the correlation between ITGAL and tumor infiltration immune cells. Also, further results were investigated by immunohistochemistry, qRT-PCR, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T00:27:37.498Z","creation":"2025-04-05T00:27:37.498Z"},"accession":"S-EPMC8987306","cross_references":{"pubmed":["35399517"],"doi":["10.3389/fcell.2022.808212"]}}