{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Chung LY"],"funding":["National Taiwan University Hospital","Ministry of Science and Technology, Taiwan","National Health Research Institutes"],"pubmed_abstract":["<b>Background:</b> Parkinson's disease (PD) is characterized by intraneuronal α-synuclein aggregation called Lewy bodies and progressive dopaminergic neurodegeneration. Toll-like receptor (TLR) signaling is a major pathway mediating inflammation. The molecular link on how neuroinflammation upregulates neuronal TLRs and induces accumulation of α-synuclein aggregates to drive synucleinopathy remains to be determined. <b>Objective:</b> Despite conditioned medium from microglia and TLR agonists were utilized to study their effects on neuronal cells, a Transwell coculture system, comprising lipopolysaccharide-activated microglia on top and retinoic acid-differentiated SH-SY5Y cells at the bottom more mimicking <i>in vivo</i> neuroinflammation, was employed to elucidate the mechanism of activate"],"journal":["Frontiers in pharmacology"],"pagination":["845930"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8987529"],"repository":["biostudies-literature"],"pubmed_title":["Neuroinflammation Upregulated Neuronal Toll-Like Receptors 2 and 4 to Drive Synucleinopathy in Neurodegeneration."],"pmcid":["PMC8987529"],"pubmed_authors":["Lin YT","Tai YC","Chen CC","Lin HY","Liu C","Lin CH","Chung LY"],"additional_accession":[]},"is_claimable":false,"name":"Neuroinflammation Upregulated Neuronal Toll-Like Receptors 2 and 4 to Drive Synucleinopathy in Neurodegeneration.","description":"<b>Background:</b> Parkinson's disease (PD) is characterized by intraneuronal α-synuclein aggregation called Lewy bodies and progressive dopaminergic neurodegeneration. Toll-like receptor (TLR) signaling is a major pathway mediating inflammation. The molecular link on how neuroinflammation upregulates neuronal TLRs and induces accumulation of α-synuclein aggregates to drive synucleinopathy remains to be determined. <b>Objective:</b> Despite conditioned medium from microglia and TLR agonists were utilized to study their effects on neuronal cells, a Transwell coculture system, comprising lipopolysaccharide-activated microglia on top and retinoic acid-differentiated SH-SY5Y cells at the bottom more mimicking <i>in vivo</i> neuroinflammation, was employed to elucidate the mechanism of activate","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T13:00:17.715Z","creation":"2025-04-06T21:52:10.617Z"},"accession":"S-EPMC8987529","cross_references":{"pubmed":["35401198"],"doi":["10.3389/fphar.2022.845930"]}}