{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Quinones AR"],"funding":["NIA NIH HHS"],"pagination":["101084"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8987641"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18"],"pubmed_abstract":["Evaluating multimorbidity combinations, racial/ethnic background, educational attainment, and sex associations with age-related cognitive changes is critical to clarifying the health, sociodemographic, and socioeconomic mechanisms associated with cognitive function in later life. Data from the 2011-2018 National Health and Aging Trends Study for respondents aged 65 years and older (N = 10,548, mean age = 77.5) were analyzed using linear mixed effect models. Racial/ethnic differences (mutually-exclusive groups: non-Latino White, non-Latino Black, and Latino) in cognitive trajectories and significant interactions with sex and education (<high school, high school, some college, and ≥ college degree) were evaluated. Models included sex, education, ever covered by Medicaid, coupled status, waist-height ratio, study cohort, and chronic disease category (no diseases; one disease; <i>advanced cardiovascular</i> multimorbidity; <i>metabolic</i> multimorbidity; <i>advanced cardiovascular-metabolic</i> multimorbidity; and <i>neither advanced cardiovascular nor metabolic</i> multimorbidity). In covariate-adjusted models, Black (b = -1.31, 95% CI: 1.74,-0.89) and Latino (b = -0.83, 95% CI: 1.58,-0.07) respondents had lower cognitive scores at age 65 and steeper declines with age (b = -0.08, 95% CI: -0.15,-0.01; b = -0.20, 95% CI: 0.34,-0.05, respectively) compared with White respondents. Cognitive scores were lower among respondents with <i>advanced cardiovascular</i> (b = -0.28, 95% CI: 0.54,-0.01) and <i>advanced cardiovascular-metabolic</i> (b = -0.56, 95% CI: 0.86,-0.27) multimorbidity compared with respondents with none of the chronic diseases of interest. In interaction models, protective associations by female sex and higher education were not observed among minority racial/ethnic groups. It is important to develop interventions to postpone cognitive decline among older Black and Latino adults."],"journal":["SSM - population health"],"pubmed_title":["Trajectories of cognitive functioning in later life: Disparities by race/ethnicity, educational attainment, sex, and multimorbidity combinations."],"pmcid":["PMC8987641"],"funding_grant_id":["P30 AG021342","RF1 AG058545","P30 AG066518","P30 AG066508"],"pubmed_authors":["Allore HG","Nagel CL","Thielke S","Botoseneanu A","Kaye J","Quinones AR","Newsom JT","Chen S"],"additional_accession":[]},"is_claimable":false,"name":"Trajectories of cognitive functioning in later life: Disparities by race/ethnicity, educational attainment, sex, and multimorbidity combinations.","description":"Evaluating multimorbidity combinations, racial/ethnic background, educational attainment, and sex associations with age-related cognitive changes is critical to clarifying the health, sociodemographic, and socioeconomic mechanisms associated with cognitive function in later life. Data from the 2011-2018 National Health and Aging Trends Study for respondents aged 65 years and older (N = 10,548, mean age = 77.5) were analyzed using linear mixed effect models. Racial/ethnic differences (mutually-exclusive groups: non-Latino White, non-Latino Black, and Latino) in cognitive trajectories and significant interactions with sex and education (<high school, high school, some college, and ≥ college degree) were evaluated. Models included sex, education, ever covered by Medicaid, coupled status, waist-height ratio, study cohort, and chronic disease category (no diseases; one disease; <i>advanced cardiovascular</i> multimorbidity; <i>metabolic</i> multimorbidity; <i>advanced cardiovascular-metabolic</i> multimorbidity; and <i>neither advanced cardiovascular nor metabolic</i> multimorbidity). In covariate-adjusted models, Black (b = -1.31, 95% CI: 1.74,-0.89) and Latino (b = -0.83, 95% CI: 1.58,-0.07) respondents had lower cognitive scores at age 65 and steeper declines with age (b = -0.08, 95% CI: -0.15,-0.01; b = -0.20, 95% CI: 0.34,-0.05, respectively) compared with White respondents. Cognitive scores were lower among respondents with <i>advanced cardiovascular</i> (b = -0.28, 95% CI: 0.54,-0.01) and <i>advanced cardiovascular-metabolic</i> (b = -0.56, 95% CI: 0.86,-0.27) multimorbidity compared with respondents with none of the chronic diseases of interest. In interaction models, protective associations by female sex and higher education were not observed among minority racial/ethnic groups. It is important to develop interventions to postpone cognitive decline among older Black and Latino adults.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-06-19T03:08:57.877Z","creation":"2025-04-04T19:10:30.255Z"},"accession":"S-EPMC8987641","cross_references":{"pubmed":["35402685"],"doi":["10.1016/j.ssmph.2022.101084"]}}