{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(4)"],"submitter":["Perez-Nadales E"],"pubmed_abstract":["<h4>Introduction</h4>Infections caused by carbapenemase-producing <i>Enterobacterales</i> are frequent and associated with high rates of mortality. Intestinal carriers are at increased risk of infection by these microorganisms. Decolonisation strategies with antibiotics have not obtained conclusive results. Faecal microbiota transplantation (FMT) could be an effective and safe strategy to decolonise intestinal carriers of KPC-producing <i>Klebsiella pneumoniae</i> (KPC-Kp) but this hypothesis needs evaluation in appropriate clinical trials.<h4>Methods and analysis</h4>The KAPEDIS trial is a single-centre, randomised, double-blind, placebo-controlled, phase 2, superiority clinical trial of FMT for eradication of intestinal colonisation by KPC-Kp. One hundred and twenty patients with rectal "],"journal":["BMJ open"],"pagination":["e058124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8987760"],"repository":["biostudies-literature"],"pubmed_title":["Randomised, double-blind, placebo-controlled, phase 2, superiority trial to demonstrate the effectiveness of faecal microbiota transplantation for selective intestinal decolonisation of patients colonised by carbapenemase-producing <i>Klebsiella pneumoniae</i> (KAPEDIS)."],"pmcid":["PMC8987760"],"pubmed_authors":["Artacho MJ","Vidal E","Doblas A","Torre-Cisneros J","Natera C","Caston JJ","Martinez-Martinez L","Perez-Nadales E","Guzman-Puche J","Cano A","Recio M"],"additional_accession":[]},"is_claimable":false,"name":"Randomised, double-blind, placebo-controlled, phase 2, superiority trial to demonstrate the effectiveness of faecal microbiota transplantation for selective intestinal decolonisation of patients colonised by carbapenemase-producing <i>Klebsiella pneumoniae</i> (KAPEDIS).","description":"<h4>Introduction</h4>Infections caused by carbapenemase-producing <i>Enterobacterales</i> are frequent and associated with high rates of mortality. Intestinal carriers are at increased risk of infection by these microorganisms. Decolonisation strategies with antibiotics have not obtained conclusive results. Faecal microbiota transplantation (FMT) could be an effective and safe strategy to decolonise intestinal carriers of KPC-producing <i>Klebsiella pneumoniae</i> (KPC-Kp) but this hypothesis needs evaluation in appropriate clinical trials.<h4>Methods and analysis</h4>The KAPEDIS trial is a single-centre, randomised, double-blind, placebo-controlled, phase 2, superiority clinical trial of FMT for eradication of intestinal colonisation by KPC-Kp. One hundred and twenty patients with rectal ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-30T23:10:53.629Z","creation":"2024-11-11T23:31:50.859Z"},"accession":"S-EPMC8987760","cross_references":{"pubmed":["35387830"],"doi":["10.1136/bmjopen-2021-058124"]}}