{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(3)"],"submitter":["Tang XY"],"pubmed_abstract":["<h4>Background</h4>The mechanisms involved in the malignant progression of lung adenocarcinoma (LUAD) are still inconclusive. Fibrinogen-like protein 1 (<i>FGL1</i>) and <i>LAG3</i> are a pair of immune checkpoints that create an inhibitory immune microenvironment in tumors. However, other roles of <i>FGL1</i> in LUAD have not been extensively studied. Our study aims to explore the role of <i>FGL1</i> in the malignant progression of LUAD and to provide new therapeutic targets and strategies for LUAD treatment.<h4>Methods</h4>Differential gene expression of <i>FGL1</i> was analyzed using the Gene Expression Profiling Interactive Analysis (GEPIA), Oncomine, UALCAN, and Gene Expression Omnibus (GEO) databases. A pan-cancer analysis was conducted using the Oncomine, TIMER, and UALCAN databases"],"journal":["Translational lung cancer research"],"pagination":["404-419"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8988074"],"repository":["biostudies-literature"],"pubmed_title":["The downregulation of fibrinogen-like protein 1 inhibits the proliferation of lung adenocarcinoma via regulating <i>MYC</i>-target genes."],"pmcid":["PMC8988074"],"pubmed_authors":["Xiong YL","Han Q","Malhotra J","Zheng KF","Ma N","Lv Y","Jiang T","Sun Y","Zhao JB","Liu YJ","Tang XY","Shi AP","Shi XG","Frattini M"],"additional_accession":[]},"is_claimable":false,"name":"The downregulation of fibrinogen-like protein 1 inhibits the proliferation of lung adenocarcinoma via regulating <i>MYC</i>-target genes.","description":"<h4>Background</h4>The mechanisms involved in the malignant progression of lung adenocarcinoma (LUAD) are still inconclusive. Fibrinogen-like protein 1 (<i>FGL1</i>) and <i>LAG3</i> are a pair of immune checkpoints that create an inhibitory immune microenvironment in tumors. However, other roles of <i>FGL1</i> in LUAD have not been extensively studied. Our study aims to explore the role of <i>FGL1</i> in the malignant progression of LUAD and to provide new therapeutic targets and strategies for LUAD treatment.<h4>Methods</h4>Differential gene expression of <i>FGL1</i> was analyzed using the Gene Expression Profiling Interactive Analysis (GEPIA), Oncomine, UALCAN, and Gene Expression Omnibus (GEO) databases. A pan-cancer analysis was conducted using the Oncomine, TIMER, and UALCAN databases","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T18:35:14.546Z","creation":"2024-11-21T11:07:46.893Z"},"accession":"S-EPMC8988074","cross_references":{"pubmed":["35399566"],"doi":["10.21037/tlcr-22-151"]}}