{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thi Cam Huong N"],"funding":["university of medicine and pharmacy at Ho Chi Minh city"],"pagination":["e0266134"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8989215"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(4)"],"pubmed_abstract":["<h4>Background</h4>Chronic hepatitis B virus (CHB) infection is a major health problem and leading cause of hepatocellular carcinoma (HCC) worldwide. Several point and deletion mutations on the PreS/S gene have been intensively considered associated with HCC. This study aimed to describe the characteristics of HBV PreS/S mutations in Vietnamese CHB-infected patients and their association with HCC.<h4>Methods</h4>This cross-sectional study was conducted from 02/2020 to 03/2021, recruited Vietnamese CHB-infected patients with HBV-DNA >3 log10-copies/mL and successful PreS/S gene sequencing. Mutations were detected by direct Sanger sequencing.<h4>Results</h4>247 CHB-infected patients were recruited, characterized by 68.8% males, 54.7% HBV genotype B, 57.5% HBeAg positive, 23.1% fibrosis score"],"journal":["PloS one"],"pubmed_title":["Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients."],"pmcid":["PMC8989215"],"funding_grant_id":["This study was funded for the PreS/S gene Sequencing by the grant of research from the University of Medicine and Pharmacy at Ho Chi Minh city"],"pubmed_authors":["Thi Cam Huong N","Tram DB","Luong BA","Bui HH","Vu HA","Trung NQ","Pham Thi Le H"],"additional_accession":[]},"is_claimable":false,"name":"Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.","description":"<h4>Background</h4>Chronic hepatitis B virus (CHB) infection is a major health problem and leading cause of hepatocellular carcinoma (HCC) worldwide. Several point and deletion mutations on the PreS/S gene have been intensively considered associated with HCC. This study aimed to describe the characteristics of HBV PreS/S mutations in Vietnamese CHB-infected patients and their association with HCC.<h4>Methods</h4>This cross-sectional study was conducted from 02/2020 to 03/2021, recruited Vietnamese CHB-infected patients with HBV-DNA >3 log10-copies/mL and successful PreS/S gene sequencing. Mutations were detected by direct Sanger sequencing.<h4>Results</h4>247 CHB-infected patients were recruited, characterized by 68.8% males, 54.7% HBV genotype B, 57.5% HBeAg positive, 23.1% fibrosis score","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T06:02:14.61Z","creation":"2025-02-19T01:54:53.627Z"},"accession":"S-EPMC8989215","cross_references":{"pubmed":["35390033"],"doi":["10.1371/journal.pone.0266134"]}}