biostudies-literatureThi Cam Huong Nuniversity of medicine and pharmacy at Ho Chi Minh citye0266134https://www.ebi.ac.uk/biostudies/studies/S-EPMC8989215biostudies-literatureUnknown17(4)<h4>Background</h4>Chronic hepatitis B virus (CHB) infection is a major health problem and leading cause of hepatocellular carcinoma (HCC) worldwide. Several point and deletion mutations on the PreS/S gene have been intensively considered associated with HCC. This study aimed to describe the characteristics of HBV PreS/S mutations in Vietnamese CHB-infected patients and their association with HCC.<h4>Methods</h4>This cross-sectional study was conducted from 02/2020 to 03/2021, recruited Vietnamese CHB-infected patients with HBV-DNA >3 log10-copies/mL and successful PreS/S gene sequencing. Mutations were detected by direct Sanger sequencing.<h4>Results</h4>247 CHB-infected patients were recruited, characterized by 68.8% males, 54.7% HBV genotype B, 57.5% HBeAg positive, 23.1% fibrosis scorePloS oneMutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.PMC8989215This study was funded for the PreS/S gene Sequencing by the grant of research from the University of Medicine and Pharmacy at Ho Chi Minh cityThi Cam Huong NTram DBLuong BABui HHVu HATrung NQPham Thi Le HfalseMutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.<h4>Background</h4>Chronic hepatitis B virus (CHB) infection is a major health problem and leading cause of hepatocellular carcinoma (HCC) worldwide. Several point and deletion mutations on the PreS/S gene have been intensively considered associated with HCC. This study aimed to describe the characteristics of HBV PreS/S mutations in Vietnamese CHB-infected patients and their association with HCC.<h4>Methods</h4>This cross-sectional study was conducted from 02/2020 to 03/2021, recruited Vietnamese CHB-infected patients with HBV-DNA >3 log10-copies/mL and successful PreS/S gene sequencing. Mutations were detected by direct Sanger sequencing.<h4>Results</h4>247 CHB-infected patients were recruited, characterized by 68.8% males, 54.7% HBV genotype B, 57.5% HBeAg positive, 23.1% fibrosis score2022-01-01T00:00:00Z20222026-05-31T06:02:14.61Z2025-02-19T01:54:53.627ZS-EPMC89892153539003310.1371/journal.pone.0266134