{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khedkar S"],"funding":["Earlham Institute (Funder)","European Research Council","EMBARK JPIAMR","European Molecular Biology Laboratory","Federal Ministry of Education and Research","Shanghai Municipal Science and Technology","Biotechnology and Biological Sciences Research Council","German Network for Bioinformatics Infrastructure"],"pagination":["3155-3168"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8989519"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["50(6)"],"pubmed_abstract":["Prokaryotic Mobile Genetic Elements (MGEs) such as transposons, integrons, phages and plasmids, play important roles in prokaryotic evolution and in the dispersal of cargo functions like antibiotic resistance. However, each of these MGE types is usually annotated and analysed individually, hampering a global understanding of phylogenetic and environmental patterns of MGE dispersal. We thus developed a computational framework that captures diverse MGE types, their cargos and MGE-mediated horizontal transfer events, using recombinases as ubiquitous MGE marker genes and pangenome information for MGE boundary estimation. Applied to ∼84k genomes with habitat annotation, we mapped 2.8 million MGE-specific recombinases to six operational MGE types, which together contain on average 13% of all the"],"journal":["Nucleic acids research"],"pubmed_title":["Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes."],"pmcid":["PMC8989519"],"funding_grant_id":["BBS/E/F/000PR10353","031L0181A","669830","BBS/E/T/000PR9818","FKZ 01Kl1706","2018SHZDZX01","ERC-AdG-669830","EI-G-FH","031A537B"],"pubmed_authors":["Barabas O","Khedkar S","Smyshlyaev G","Coelho LP","Orakov A","Hildebrand F","Letunic I","Bork P","Maistrenko OM","Schmidt TSB","Forslund SK","Luetge M"],"additional_accession":[]},"is_claimable":false,"name":"Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.","description":"Prokaryotic Mobile Genetic Elements (MGEs) such as transposons, integrons, phages and plasmids, play important roles in prokaryotic evolution and in the dispersal of cargo functions like antibiotic resistance. However, each of these MGE types is usually annotated and analysed individually, hampering a global understanding of phylogenetic and environmental patterns of MGE dispersal. We thus developed a computational framework that captures diverse MGE types, their cargos and MGE-mediated horizontal transfer events, using recombinases as ubiquitous MGE marker genes and pangenome information for MGE boundary estimation. Applied to ∼84k genomes with habitat annotation, we mapped 2.8 million MGE-specific recombinases to six operational MGE types, which together contain on average 13% of all the","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-04-08T18:19:33.612Z","creation":"2025-04-04T19:30:28.8Z"},"accession":"S-EPMC8989519","cross_references":{"pubmed":["35323968"],"doi":["10.1093/nar/gkac163"]}}