biostudies-literatureUnknown2022Liu YThe traditional Chinese medicine <i>Gastrodia elata</i> (commonly called "Tianma" in Chinese) has been widely used in the treatment of rheumatism, epilepsy, paralysis, headache, and dizziness. Phenolic compounds, such as gastrodin, <i>para</i>-hydroxybenzyl alcohol (HBA), <i>p</i>-hydroxybenzaldehyde, and vanillin are the main bioactive components isolated from <i>Gastrodia elata</i>. These compounds not only are structurally related but also share similar pharmacological activities, such as antioxidative and anti-inflammatory activities, and effects on the treatment of aging-related diseases. Here, we investigated the effect of <i>para</i>-hydroxybenzyl alcohol (HBA) on neurodegenerative diseases and aging in models of <i>Caenorhabditis elegans</i> (<i>C. elegans</i>). Our results showed Oxidative medicine and cellular longevity8986287https://www.ebi.ac.uk/biostudies/studies/S-EPMC8989581biostudies-literature<i>Para</i>-Hydroxybenzyl Alcohol Delays the Progression of Neurodegenerative Diseases in Models of <i>Caenorhabditis elegans</i> through Activating Multiple Cellular Protective Pathways.PMC8989581Luo HRLiu YWu GSShi LLu YYXiao HTZheng ZYHuang LQu YChen JNfalse<i>Para</i>-Hydroxybenzyl Alcohol Delays the Progression of Neurodegenerative Diseases in Models of <i>Caenorhabditis elegans</i> through Activating Multiple Cellular Protective Pathways.The traditional Chinese medicine <i>Gastrodia elata</i> (commonly called "Tianma" in Chinese) has been widely used in the treatment of rheumatism, epilepsy, paralysis, headache, and dizziness. Phenolic compounds, such as gastrodin, <i>para</i>-hydroxybenzyl alcohol (HBA), <i>p</i>-hydroxybenzaldehyde, and vanillin are the main bioactive components isolated from <i>Gastrodia elata</i>. These compounds not only are structurally related but also share similar pharmacological activities, such as antioxidative and anti-inflammatory activities, and effects on the treatment of aging-related diseases. Here, we investigated the effect of <i>para</i>-hydroxybenzyl alcohol (HBA) on neurodegenerative diseases and aging in models of <i>Caenorhabditis elegans</i> (<i>C. elegans</i>). Our results showed 2022-01-01T00:00:00Z20222025-04-19T21:49:28.799Z2025-04-19T21:49:28.799ZS-EPMC89895813540193010.1155/2022/8986287