biostudies-literatureSsuuna CCCR NIH HHSFIC NIH HHSNIAID NIH HHSNIMH NIH HHSFogarty International CenterNational Cancer InstituteNational Institute of Mental HealthNCI NIH HHSDivision of Intramural Research, National Institute of Allergy and Infectious Diseasese050436https://www.ebi.ac.uk/biostudies/studies/S-EPMC8990708biostudies-literatureUnknown12(4)<h4>Objective</h4>To investigate hepatitis B virus (HBV) prevalence and factors associated with viral acquisition in a HIV-hyperendemic fishing community, we tested sera for anti-hepatitis B core (HBc) and hepatitis B surface antigen (HBsAg).<h4>Design</h4>Observational cross-sectional study.<h4>Setting</h4>Large fishing village on Lake Victoria, one of the HIV-hyperendemic Rakai Community Cohort Study (RCCS) sites (HIV prevalence ~40%).<h4>Participants</h4>Sample of 460 RCCS participants aged 15-49 years from survey conducted from 5 December 2016 to 13 February 2017. These proportionately included HIV-negative, HIV-positive antiretroviral therapy (ART)-naïve and HIV positive on ART participants.<h4>Results</h4>Of the 460 participants, 49.6% (95% CI 45.0% to 54.1%) had evidence of prior HBBMJ openHepatitis B virus infection and factors associated with its acquisition among adults in a Lake Victoria HIV hyperendemic fishing community in Kyotera district, Uganda: a cross-sectional observation.PMC8990708R01MH107275D43TW010557R01 AI143333HHSN261200800001EHHSN261200800001CR01MH090173R01AI143333R01 MH107275R01 MH090173D43 TW010557Chang LKalibbala SYeh PTSsempijja VWawer MGray RSerwadda DReynolds SKagaayi JSsuuna CfalseHepatitis B virus infection and factors associated with its acquisition among adults in a Lake Victoria HIV hyperendemic fishing community in Kyotera district, Uganda: a cross-sectional observation.<h4>Objective</h4>To investigate hepatitis B virus (HBV) prevalence and factors associated with viral acquisition in a HIV-hyperendemic fishing community, we tested sera for anti-hepatitis B core (HBc) and hepatitis B surface antigen (HBsAg).<h4>Design</h4>Observational cross-sectional study.<h4>Setting</h4>Large fishing village on Lake Victoria, one of the HIV-hyperendemic Rakai Community Cohort Study (RCCS) sites (HIV prevalence ~40%).<h4>Participants</h4>Sample of 460 RCCS participants aged 15-49 years from survey conducted from 5 December 2016 to 13 February 2017. These proportionately included HIV-negative, HIV-positive antiretroviral therapy (ART)-naïve and HIV positive on ART participants.<h4>Results</h4>Of the 460 participants, 49.6% (95% CI 45.0% to 54.1%) had evidence of prior HB2022-01-01T00:00:00Z2022 Apr2025-06-01T01:33:11.537Z2025-06-01T01:33:11.537ZS-EPMC89907083539330610.1136/bmjopen-2021-050436