biostudies-literatureUnknown13Tano S<h4>Introduction</h4>Weight change during the interpregnancy is related to gestational diabetes mellitus (GDM) in the subsequent pregnancy. In interpregnancy care/counseling, the timeframe for goal setting is important, while the timing of the next conception is unpredictable and preventing age-related body weight gain is difficult. This study aimed to investigate the association between annual weight gain during the interpregnancy, which provide clearer timeframe, and GDM in subsequent pregnancies.<h4>Methods</h4>This multicenter retrospective study was conducted by collecting data on two pregnancies of the same women in 2009-2019. The association between annual BMI gain and GDM during the subsequent pregnancy was examined.<h4>Results</h4>This study included 1,640 pregnant women. A history of GDM [adjusted odds ratio (aOR), 26.22; 95% confidence interval (CI), 14.93-46.07] and annual BMI gain (aOR, 1.48; 95% CI, 1.22-1.81) were related to GDM during the subsequent pregnancy. In the women with a pre-pregnant BMI of <25.0 kg/m² and without GDM during the index pregnancy, an annual BMI gain of ≥0.6 kg/m²/year during the interpregnancy were associated with GDM in subsequent pregnancies; however, in the other subgroups, it was not associated with GDM in subsequent pregnancies.<h4>Conclusions</h4>For women with a pre-pregnant BMI of <25.0 kg/m² and without GDM during the index pregnancy, maintaining an annual BMI gain of <0.6 kg/m²/year may prevent GDM during the subsequent pregnancy.Frontiers in endocrinology815390https://www.ebi.ac.uk/biostudies/studies/S-EPMC8990746biostudies-literatureAnnual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy.PMC8990746Tano SNakano-Kobayashi TIitani YKinoshita FYoshida SOguchi HKotani TImai KUshida TMoriyama YKishigami YYoshihara MKajiyama HYamashita MfalseAnnual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy.<h4>Introduction</h4>Weight change during the interpregnancy is related to gestational diabetes mellitus (GDM) in the subsequent pregnancy. In interpregnancy care/counseling, the timeframe for goal setting is important, while the timing of the next conception is unpredictable and preventing age-related body weight gain is difficult. This study aimed to investigate the association between annual weight gain during the interpregnancy, which provide clearer timeframe, and GDM in subsequent pregnancies.<h4>Methods</h4>This multicenter retrospective study was conducted by collecting data on two pregnancies of the same women in 2009-2019. The association between annual BMI gain and GDM during the subsequent pregnancy was examined.<h4>Results</h4>This study included 1,640 pregnant women. A history of GDM [adjusted odds ratio (aOR), 26.22; 95% confidence interval (CI), 14.93-46.07] and annual BMI gain (aOR, 1.48; 95% CI, 1.22-1.81) were related to GDM during the subsequent pregnancy. In the women with a pre-pregnant BMI of <25.0 kg/m² and without GDM during the index pregnancy, an annual BMI gain of ≥0.6 kg/m²/year during the interpregnancy were associated with GDM in subsequent pregnancies; however, in the other subgroups, it was not associated with GDM in subsequent pregnancies.<h4>Conclusions</h4>For women with a pre-pregnant BMI of <25.0 kg/m² and without GDM during the index pregnancy, maintaining an annual BMI gain of <0.6 kg/m²/year may prevent GDM during the subsequent pregnancy.2022-01-01T00:00:00Z20222025-04-05T14:43:07.982Z2025-04-05T14:43:07.982ZS-EPMC89907463539993210.3389/fendo.2022.815390