biostudies-literatureUnknown30(4)Canzian FThere is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low individual penetrance. Combining the SNPs in a polygenic risk score (PRS) is a possible approach to improve their usefulness. Using 2361 MM cases and 1415 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, we computed a weighted and an unweighted PRS. We observed associations with MM risk with OR = 3.44, 95% CI 2.53-4.69, p = 3.55 × 10^-15 for the highest vs. lowest quintile of the weighted score, and OR = 3.18, 95% CI 2.1 = 34-4.33, p = 1.62 × 10^-13 for the highest vs. lowest quintile of the unEuropean journal of human genetics : EJHG474-479https://www.ebi.ac.uk/biostudies/studies/S-EPMC8991223biostudies-literatureA polygenic risk score for multiple myeloma risk prediction.PMC8991223Vangsted AJDruzd-Sitek AAndersen VWatek MLesueur FButrym APetrini MVarkonyi JBeider KVogel UMacauda AAndersen NFSainz JDudzinski MMarques HKruszewski MRymko MJurczyszyn AKadar KZaucha JMJamroziak KGemignani FDumontet CAbildgaard NPelosini MBuda GReis RMSubocz EOrciuolo ERazny MPiredda CTomczak WMazur GNagler ASuska AAvet-Loiseau HZawirska DCanzian FMinvielle SCampa DfalseA polygenic risk score for multiple myeloma risk prediction.There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low individual penetrance. Combining the SNPs in a polygenic risk score (PRS) is a possible approach to improve their usefulness. Using 2361 MM cases and 1415 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, we computed a weighted and an unweighted PRS. We observed associations with MM risk with OR = 3.44, 95% CI 2.53-4.69, p = 3.55 × 10^-15 for the highest vs. lowest quintile of the weighted score, and OR = 3.18, 95% CI 2.1 = 34-4.33, p = 1.62 × 10^-13 for the highest vs. lowest quintile of the un2022-01-01T00:00:00Z2022 Apr2026-05-30T15:28:12.168Z2025-04-04T10:02:19.694ZS-EPMC89912233484533410.1038/s41431-021-00986-8