{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Krishnadas N"],"pubmed_abstract":["<h4>Background</h4>Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ-) occurs with aging. The tau PET tracer <sup>18</sup>F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ- cognitively unimpaired (CU) individuals.<h4>Methods</h4>One hundred and ninety-nine Aβ- participants (Centiloid < 25) who were CU underwent <sup>18</sup>F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuou"],"journal":["Alzheimer's research & therapy"],"pagination":["51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8991917"],"repository":["biostudies-literature"],"pubmed_title":["Mesial temporal tau in amyloid-β-negative cognitively normal older persons."],"pmcid":["PMC8991917"],"pubmed_authors":["Bourgeat P","Goh AMY","Burnham SC","Rowe CC","Krishnadas N","Lamb F","Huang K","Villemagne VL","Masters CL","AIBL research group","Dore V","Groot C"],"additional_accession":[]},"is_claimable":false,"name":"Mesial temporal tau in amyloid-β-negative cognitively normal older persons.","description":"<h4>Background</h4>Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ-) occurs with aging. The tau PET tracer <sup>18</sup>F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ- cognitively unimpaired (CU) individuals.<h4>Methods</h4>One hundred and ninety-nine Aβ- participants (Centiloid < 25) who were CU underwent <sup>18</sup>F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuou","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-22T03:57:14.905Z","creation":"2025-04-05T20:49:03.209Z"},"accession":"S-EPMC8991917","cross_references":{"pubmed":["35395950"],"doi":["10.1186/s13195-022-00993-x"]}}