biostudies-literatureUnknown14(1)Krishnadas N<h4>Background</h4>Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ-) occurs with aging. The tau PET tracer ¹⁸F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ- cognitively unimpaired (CU) individuals.<h4>Methods</h4>One hundred and ninety-nine Aβ- participants (Centiloid < 25) who were CU underwent ¹⁸F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuouAlzheimer's research & therapy51https://www.ebi.ac.uk/biostudies/studies/S-EPMC8991917biostudies-literatureMesial temporal tau in amyloid-β-negative cognitively normal older persons.PMC8991917Bourgeat PGoh AMYBurnham SCRowe CCKrishnadas NLamb FHuang KVillemagne VLMasters CLAIBL research groupDore VGroot CfalseMesial temporal tau in amyloid-β-negative cognitively normal older persons.<h4>Background</h4>Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ-) occurs with aging. The tau PET tracer ¹⁸F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ- cognitively unimpaired (CU) individuals.<h4>Methods</h4>One hundred and ninety-nine Aβ- participants (Centiloid < 25) who were CU underwent ¹⁸F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuou2022-01-01T00:00:00Z2022 Apr2025-04-22T03:57:14.905Z2025-04-05T20:49:03.209ZS-EPMC89919173539595010.1186/s13195-022-00993-x