{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(18)"],"submitter":["Liu B"],"pubmed_abstract":["Real-time monitoring of drug release behaviors over extended periods of time is critical in understanding the dynamics of drug progression for personalized chemotherapeutic treatment. In this work, we report a metal-organic framework (MOF)-based nanotheranostic system encapsulated with photothermal agents (CuS) and therapeutic drug (DOX) to achieve the capabilities of real-time drug release monitoring and combined chemo-photothermal therapy. Meanwhile, folic acid-conjugated polyethylene glycol (FA-PEG) antennas were connected to the MOF through coordination interactions, endowing the MOF with an enhanced active targeting effect toward cancer cells. It is anticipated that such a theranostic agent, simultaneously possessing tumor-targeting, real-time drug monitoring and effective treatment, "],"journal":["RSC advances"],"pagination":["11119-11127"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8992360"],"repository":["biostudies-literature"],"pubmed_title":["Real-time drug release monitoring from pH-responsive CuS-encapsulated metal-organic frameworks."],"pmcid":["PMC8992360"],"pubmed_authors":["Sun L","Peng H","Yang Y","Lu X","Chu H","Liu B","Sun Z","Xu J"],"additional_accession":[]},"is_claimable":false,"name":"Real-time drug release monitoring from pH-responsive CuS-encapsulated metal-organic frameworks.","description":"Real-time monitoring of drug release behaviors over extended periods of time is critical in understanding the dynamics of drug progression for personalized chemotherapeutic treatment. In this work, we report a metal-organic framework (MOF)-based nanotheranostic system encapsulated with photothermal agents (CuS) and therapeutic drug (DOX) to achieve the capabilities of real-time drug release monitoring and combined chemo-photothermal therapy. Meanwhile, folic acid-conjugated polyethylene glycol (FA-PEG) antennas were connected to the MOF through coordination interactions, endowing the MOF with an enhanced active targeting effect toward cancer cells. It is anticipated that such a theranostic agent, simultaneously possessing tumor-targeting, real-time drug monitoring and effective treatment, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-26T15:15:19.387Z","creation":"2025-04-06T14:53:37.291Z"},"accession":"S-EPMC8992360","cross_references":{"pubmed":["35425048"],"doi":["10.1039/d1ra09320g"]}}