biostudies-literatureUnknown12(18)Liu BReal-time monitoring of drug release behaviors over extended periods of time is critical in understanding the dynamics of drug progression for personalized chemotherapeutic treatment. In this work, we report a metal-organic framework (MOF)-based nanotheranostic system encapsulated with photothermal agents (CuS) and therapeutic drug (DOX) to achieve the capabilities of real-time drug release monitoring and combined chemo-photothermal therapy. Meanwhile, folic acid-conjugated polyethylene glycol (FA-PEG) antennas were connected to the MOF through coordination interactions, endowing the MOF with an enhanced active targeting effect toward cancer cells. It is anticipated that such a theranostic agent, simultaneously possessing tumor-targeting, real-time drug monitoring and effective treatment, RSC advances11119-11127https://www.ebi.ac.uk/biostudies/studies/S-EPMC8992360biostudies-literatureReal-time drug release monitoring from pH-responsive CuS-encapsulated metal-organic frameworks.PMC8992360Sun LPeng HYang YLu XChu HLiu BSun ZXu JfalseReal-time drug release monitoring from pH-responsive CuS-encapsulated metal-organic frameworks.Real-time monitoring of drug release behaviors over extended periods of time is critical in understanding the dynamics of drug progression for personalized chemotherapeutic treatment. In this work, we report a metal-organic framework (MOF)-based nanotheranostic system encapsulated with photothermal agents (CuS) and therapeutic drug (DOX) to achieve the capabilities of real-time drug release monitoring and combined chemo-photothermal therapy. Meanwhile, folic acid-conjugated polyethylene glycol (FA-PEG) antennas were connected to the MOF through coordination interactions, endowing the MOF with an enhanced active targeting effect toward cancer cells. It is anticipated that such a theranostic agent, simultaneously possessing tumor-targeting, real-time drug monitoring and effective treatment, 2022-01-01T00:00:00Z2022 Apr2025-04-26T15:15:19.387Z2025-04-06T14:53:37.291ZS-EPMC89923603542504810.1039/d1ra09320g