{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(4)"],"submitter":["Randazzo O"],"pubmed_abstract":["<b>Aim:</b> Because mutations of splicing factor 3B subunit-1 (SF3B1) have been identified in 4% of pancreatic ductal adenocarcinoma (PDAC) patients, we investigated the activity of new potential inhibitors of SF3B1 in combination with gemcitabine, one of the standard drugs, in PDAC cell lines. <b>Methods:</b> One imidazo[2,1-<i>b</i>][1,3,4]thiadiazole derivative (IS1) and three indole derivatives (IS2, IS3 and IS4), selected by virtual screening from an in-house library, were evaluated by the sulforhodamine-B and wound healing assay for their cytotoxic and antimigratory activity in the PDAC cells SUIT-2, Hs766t and Panc05.04, the latter harbouring the SF3B1 mutations. The effects on the splicing pattern of proto-oncogene recepteur d'origine nantais (RON) and the gemcitabine transporter h"],"journal":["Cancer drug resistance (Alhambra, Calif.)"],"pagination":["904-922"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8992438"],"repository":["biostudies-literature"],"pubmed_title":["SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance."],"pmcid":["PMC8992438"],"pubmed_authors":["Pecoraro C","Carbone D","Diana P","Perricone U","Cascioferro SM","Avan A","Parrino B","Giovannetti E","Randazzo O","Iddouch WA","Peters GJ"],"additional_accession":[]},"is_claimable":false,"name":"SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance.","description":"<b>Aim:</b> Because mutations of splicing factor 3B subunit-1 (SF3B1) have been identified in 4% of pancreatic ductal adenocarcinoma (PDAC) patients, we investigated the activity of new potential inhibitors of SF3B1 in combination with gemcitabine, one of the standard drugs, in PDAC cell lines. <b>Methods:</b> One imidazo[2,1-<i>b</i>][1,3,4]thiadiazole derivative (IS1) and three indole derivatives (IS2, IS3 and IS4), selected by virtual screening from an in-house library, were evaluated by the sulforhodamine-B and wound healing assay for their cytotoxic and antimigratory activity in the PDAC cells SUIT-2, Hs766t and Panc05.04, the latter harbouring the SF3B1 mutations. The effects on the splicing pattern of proto-oncogene recepteur d'origine nantais (RON) and the gemcitabine transporter h","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T19:31:59.266Z","creation":"2025-02-19T02:57:55.004Z"},"accession":"S-EPMC8992438","cross_references":{"pubmed":["35582381"],"doi":["10.20517/cdr.2021.61"]}}