{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(4)"],"submitter":["Zhang BJ"],"pubmed_abstract":["Epigenetic regulation refers to alterations to the chromatin template that collectively establish differential patterns of gene transcription. Post-translational modifications of the histones play a key role in epigenetic regulation of gene transcription. In this review, we provide an overview of recent studies on the role of histone modifications in carcinogenesis. Since tumour-selective ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) are well-considered as promising anti-tumour therapies, we summarise strategies for improving TRAIL sensitivity by inhibiting aberrant histone modifications in cancers. In this perspective we also discuss new epigenetic drug targets for enhancing TRAIL-mediated apoptosis."],"journal":["Cancer drug resistance (Alhambra, Calif.)"],"pagination":["791-803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8992553"],"repository":["biostudies-literature"],"pubmed_title":["Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications."],"pmcid":["PMC8992553"],"pubmed_authors":["Quax WJ","Zhang BJ","Chen D","Dekker FJ"],"additional_accession":[]},"is_claimable":false,"name":"Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications.","description":"Epigenetic regulation refers to alterations to the chromatin template that collectively establish differential patterns of gene transcription. Post-translational modifications of the histones play a key role in epigenetic regulation of gene transcription. In this review, we provide an overview of recent studies on the role of histone modifications in carcinogenesis. Since tumour-selective ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) are well-considered as promising anti-tumour therapies, we summarise strategies for improving TRAIL sensitivity by inhibiting aberrant histone modifications in cancers. In this perspective we also discuss new epigenetic drug targets for enhancing TRAIL-mediated apoptosis.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-05-18T12:04:48.949Z","creation":"2025-04-05T20:38:38.415Z"},"accession":"S-EPMC8992553","cross_references":{"pubmed":["35582230"],"doi":["10.20517/cdr.2020.58"]}}