{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Fang ZE"],"pubmed_abstract":["Aristolochic acid (AA) is a group of structurally related compounds what have been used to treat various diseases in recent decades. Aristolochic acid I (AAI), an important ingredient, has been associated with tumorigenesis. Recently, some studies indicated that AAI could induce liver injury in mice of different age, but comprehensive mechanisms of AAI-induced differences in liver injury in various age groups have not yet been elucidated. This study aims to evaluate the causal relationship between AAI-induced liver injury and age based on neonatal mice and adult mice. A survival experiment indicated that all neonatal mice survived. Moreover, the adult mice in the high-dose AAI group all died, whereas half of the adult mice in the low-dose AAI group died. In observation experiments, AAI ind"],"journal":["Frontiers in genetics"],"pagination":["840961"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8992794"],"repository":["biostudies-literature"],"pubmed_title":["Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I."],"pmcid":["PMC8992794"],"pubmed_authors":["Fang ZE","Wang C","Xiao X","Li Q","Bai Z","Liu T","Wei Z","Li Z","Ren L","Gao Y","Niu M","Mu W","Lin L"],"additional_accession":[]},"is_claimable":false,"name":"Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I.","description":"Aristolochic acid (AA) is a group of structurally related compounds what have been used to treat various diseases in recent decades. Aristolochic acid I (AAI), an important ingredient, has been associated with tumorigenesis. Recently, some studies indicated that AAI could induce liver injury in mice of different age, but comprehensive mechanisms of AAI-induced differences in liver injury in various age groups have not yet been elucidated. This study aims to evaluate the causal relationship between AAI-induced liver injury and age based on neonatal mice and adult mice. A survival experiment indicated that all neonatal mice survived. Moreover, the adult mice in the high-dose AAI group all died, whereas half of the adult mice in the low-dose AAI group died. In observation experiments, AAI ind","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T12:58:52.506Z","creation":"2025-04-19T12:58:52.506Z"},"accession":"S-EPMC8992794","cross_references":{"pubmed":["35401701"],"doi":["10.3389/fgene.2022.840961"]}}