biostudies-literatureGupta RHHS | NIH | National Cancer InstituteNCI NIH HHSC762-C768https://www.ebi.ac.uk/biostudies/studies/S-EPMC8993518biostudies-literatureUnknown322(4)The tumor microenvironment (TME) composed of different types of cells embedded in extracellular matrix (ECM) has crucial effects on cancer growth and metastasis. ECM is made of a variety of proteins that provide structural support to the cells and regulate biological functions by modulating the cross talk among cells, thus effecting tumor growth and progression. In this mini-review, the author discusses epigenetic modifications that regulate the expression of fibrous ECM proteins and glycoproteins and the prospects of targeting them for cancer therapy.American journal of physiology. Cell physiologyEpigenetic regulation and targeting of ECM for cancer therapy.PMC8993518R01CA233481R03CA230815R03 CA230815R01 CA233481R03 CA248913R03CA248913Gupta RfalseEpigenetic regulation and targeting of ECM for cancer therapy.The tumor microenvironment (TME) composed of different types of cells embedded in extracellular matrix (ECM) has crucial effects on cancer growth and metastasis. ECM is made of a variety of proteins that provide structural support to the cells and regulate biological functions by modulating the cross talk among cells, thus effecting tumor growth and progression. In this mini-review, the author discusses epigenetic modifications that regulate the expression of fibrous ECM proteins and glycoproteins and the prospects of targeting them for cancer therapy.2022-01-01T00:00:00Z2022 Apr2025-04-26T13:09:23.428Z2025-04-06T14:10:53.388ZS-EPMC89935183523542710.1152/ajpcell.00022.2022