{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Luo H"],"pubmed_abstract":["The underlying mechanisms of methionine adenosyltransferase 2 A (MAT2A)-mediated cervical cancer progression under nutrient stress are largely elusive. Therefore, our study aims to investigate molecular mechanism by which MAT2A-indcued cervical oncogenesis. The interaction between MAT2A and programmed cell death protein 6 (PDCD6) in cervical cancer cell lines was detected by immunoprecipitation, immunoblotting and mass spectrometric analysis. A panel of inhibitors that are linked to stress responsive kinases were utilized to detect related pathways by immunoblotting. Cell proliferation and apoptosis were investigated by CCK-8 and flow cytometry. Apoptosis related protein level of Bcl-2, Bax and Caspase-3 was also analyzed in cells with PDCD6 K90 methylation mutation. The association betwee"],"journal":["Cell death discovery"],"pagination":["176"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8993843"],"repository":["biostudies-literature"],"pubmed_title":["MAT2A facilitates PDCD6 methylation and promotes cell growth under glucose deprivation in cervical cancer."],"pmcid":["PMC8993843"],"pubmed_authors":["Liu Y","Chen F","Zhu X","Luo H","Wang Z","Zhang JA","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"MAT2A facilitates PDCD6 methylation and promotes cell growth under glucose deprivation in cervical cancer.","description":"The underlying mechanisms of methionine adenosyltransferase 2 A (MAT2A)-mediated cervical cancer progression under nutrient stress are largely elusive. Therefore, our study aims to investigate molecular mechanism by which MAT2A-indcued cervical oncogenesis. The interaction between MAT2A and programmed cell death protein 6 (PDCD6) in cervical cancer cell lines was detected by immunoprecipitation, immunoblotting and mass spectrometric analysis. A panel of inhibitors that are linked to stress responsive kinases were utilized to detect related pathways by immunoblotting. Cell proliferation and apoptosis were investigated by CCK-8 and flow cytometry. Apoptosis related protein level of Bcl-2, Bax and Caspase-3 was also analyzed in cells with PDCD6 K90 methylation mutation. The association betwee","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T22:16:53.443Z","creation":"2025-04-04T22:16:53.443Z"},"accession":"S-EPMC8993843","cross_references":{"pubmed":["35396512"],"doi":["10.1038/s41420-022-00987-6"]}}