{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tan Y"],"funding":["Jiangsu provincial key research and development program","National Natural Science Foundation of China","Six Talent Peaks Project in Jiangsu Province"],"pagination":["319"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8993870"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["Activated hepatic stellate cells (HSCs) are significant in liver fibrosis. Our past investigations have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their secreted exosomes (MSC-ex) could alleviate liver fibrosis via restraining HSCs activation. However, the mechanisms underlying the efficacy were not clear. Ferroptosis is a regulatory cell death caused by excessive lipid peroxidation, and it plays a vital role in the occurrence and development of liver fibrosis. In the present study, we aimed to study the proferroptosis effect and mechanism of MSC-ex in HSCs. MSC-ex were collected and purified from human umbilical cord MSCs. Proferroptosis effect of MSC-ex was examined in HSCs line LX-2 and CCl4 induced liver fibrosis in mice. Gene knockdown or overexpression appro"],"journal":["Cell death & disease"],"pubmed_title":["HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis."],"pmcid":["PMC8993870"],"funding_grant_id":["81670549","WSW-071"],"pubmed_authors":["Qian H","Liu J","Huang Y","Tan Y","Mao F","Yang D","Yan Y","Xu W","Mei R"],"additional_accession":[]},"is_claimable":false,"name":"HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis.","description":"Activated hepatic stellate cells (HSCs) are significant in liver fibrosis. Our past investigations have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their secreted exosomes (MSC-ex) could alleviate liver fibrosis via restraining HSCs activation. However, the mechanisms underlying the efficacy were not clear. Ferroptosis is a regulatory cell death caused by excessive lipid peroxidation, and it plays a vital role in the occurrence and development of liver fibrosis. In the present study, we aimed to study the proferroptosis effect and mechanism of MSC-ex in HSCs. MSC-ex were collected and purified from human umbilical cord MSCs. Proferroptosis effect of MSC-ex was examined in HSCs line LX-2 and CCl4 induced liver fibrosis in mice. Gene knockdown or overexpression appro","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-18T05:00:21.252Z","creation":"2025-04-21T16:51:51.962Z"},"accession":"S-EPMC8993870","cross_references":{"pubmed":["35395830"],"doi":["10.1038/s41419-022-04764-2"]}}