{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Prem S"],"funding":["Bundesministerium für Bildung und Forschung","Freie Universität Berlin"],"pagination":["58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8994360"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["Fatty acid hydratases are unique to microorganisms. Their native function is the oxidation of unsaturated C-C bonds to enable detoxification of environmental toxins. Within this enzyme family, the oleate hydratases (Ohys), which catalyze the hydroxylation of oleic acid to 10-(R)-hydroxy stearic acid (10-HSA) have recently gained particular industrial interest. 10-HSA is considered to be a replacement for 12-(R)-hydroxy stearic acid (12-HSA), which has a broad application in the chemical and pharmaceutical industry. As 12-HSA is obtained through an energy consuming synthesis process, the biotechnological route for sustainable 10-HSA production is of significant industrial interest. All Ohys identified to date have a non-redox active FAD bound in their active site. Ohys can be divided in sev"],"journal":["Microbial cell factories"],"pubmed_title":["Towards an understanding of oleate hydratases and their application in industrial processes."],"pmcid":["PMC8994360"],"funding_grant_id":["03SF0577A","031B0853"],"pubmed_authors":["Helmer CPO","Dimos N","Bruck T","Prem S","Garbe D","Loll B","Himpich S"],"additional_accession":[]},"is_claimable":false,"name":"Towards an understanding of oleate hydratases and their application in industrial processes.","description":"Fatty acid hydratases are unique to microorganisms. Their native function is the oxidation of unsaturated C-C bonds to enable detoxification of environmental toxins. Within this enzyme family, the oleate hydratases (Ohys), which catalyze the hydroxylation of oleic acid to 10-(R)-hydroxy stearic acid (10-HSA) have recently gained particular industrial interest. 10-HSA is considered to be a replacement for 12-(R)-hydroxy stearic acid (12-HSA), which has a broad application in the chemical and pharmaceutical industry. As 12-HSA is obtained through an energy consuming synthesis process, the biotechnological route for sustainable 10-HSA production is of significant industrial interest. All Ohys identified to date have a non-redox active FAD bound in their active site. Ohys can be divided in sev","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-31T21:04:25.252Z","creation":"2025-04-04T19:30:29.025Z"},"accession":"S-EPMC8994360","cross_references":{"pubmed":["35397585"],"doi":["10.1186/s12934-022-01777-6"]}}