{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Semmes EC"],"funding":["National Institute of Allery and Infectious Diseases","NCATS NIH HHS","NIAID NIH HHS","BERD Methods Core","National Center For Advancing Translational Sciences","National Cancer Institute","NCI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["1131-1140"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8994583"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(7)"],"pubmed_abstract":["<h4>Background</h4>Placentally transferred maternal immunoglobulin G (IgG) protects against pathogens in early life, yet vertically transmitted infections can interfere with transplacental IgG transfer. Although human cytomegalovirus (HCMV) is the most common placentally-transmitted viral infection worldwide, the impact of congenital HCMV (cCMV) infection on transplacental IgG transfer has been underexplored.<h4>Methods</h4>We evaluated total and antigen-specific maternal and cord blood IgG levels and transplacental IgG transfer efficiency in a US-based cohort of 93 mother-infant pairs including 27 cCMV-infected and 66 cCMV-uninfected pairs, of which 29 infants were born to HCMV-seropositive nontransmitting mothers and 37 to HCMV-seronegative mothers. Controls were matched on sex, race/ethnicity, maternal age, and delivery year.<h4>Results</h4>Transplacental IgG transfer efficiency was decreased by 23% (95% confidence interval [CI] 10-36%, P = .0079) in cCMV-infected pairs and 75% of this effect (95% CI 28-174%, P = .0085) was mediated by elevated maternal IgG levels (ie, hypergammaglobulinemia) in HCMV-transmitting women. Despite reduced transfer efficiency, IgG levels were similar in cord blood from infants with and without cCMV infection.<h4>Conclusions</h4>Our results indicate that cCMV infection moderately reduces transplacental IgG transfer efficiency due to maternal hypergammaglobulinemia; however, infants with and without cCMV infection had similar antigen-specific IgG levels, suggesting comparable protection from maternal IgG acquired via transplacental transfer."],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pubmed_title":["Congenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia."],"pmcid":["PMC8994583"],"funding_grant_id":["R21 AI147992","1R21-AI147992","UL1TR002553","UL1 TR002553","T32 GM145449","T32 GM007171","R21 CA242439","1R21CA242439-01"],"pubmed_authors":["Yang Z","Permar SR","Li SH","Hurst JH","Walsh KM","Kurtzberg J","Niedzwiecki D","Semmes EC","Fouda GG"],"additional_accession":[]},"is_claimable":false,"name":"Congenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia.","description":"<h4>Background</h4>Placentally transferred maternal immunoglobulin G (IgG) protects against pathogens in early life, yet vertically transmitted infections can interfere with transplacental IgG transfer. Although human cytomegalovirus (HCMV) is the most common placentally-transmitted viral infection worldwide, the impact of congenital HCMV (cCMV) infection on transplacental IgG transfer has been underexplored.<h4>Methods</h4>We evaluated total and antigen-specific maternal and cord blood IgG levels and transplacental IgG transfer efficiency in a US-based cohort of 93 mother-infant pairs including 27 cCMV-infected and 66 cCMV-uninfected pairs, of which 29 infants were born to HCMV-seropositive nontransmitting mothers and 37 to HCMV-seronegative mothers. Controls were matched on sex, race/ethnicity, maternal age, and delivery year.<h4>Results</h4>Transplacental IgG transfer efficiency was decreased by 23% (95% confidence interval [CI] 10-36%, P = .0079) in cCMV-infected pairs and 75% of this effect (95% CI 28-174%, P = .0085) was mediated by elevated maternal IgG levels (ie, hypergammaglobulinemia) in HCMV-transmitting women. Despite reduced transfer efficiency, IgG levels were similar in cord blood from infants with and without cCMV infection.<h4>Conclusions</h4>Our results indicate that cCMV infection moderately reduces transplacental IgG transfer efficiency due to maternal hypergammaglobulinemia; however, infants with and without cCMV infection had similar antigen-specific IgG levels, suggesting comparable protection from maternal IgG acquired via transplacental transfer.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-19T03:18:12.326Z","creation":"2025-04-04T03:20:09.542Z"},"accession":"S-EPMC8994583","cross_references":{"pubmed":["34260701"],"doi":["10.1093/cid/ciab627"]}}