{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lumley SF"],"funding":["Wellcome Trust Clinical Career Development Fellow","National Institute for Health Research Health Protection Research Unit","NIHR Biomedical Research Centre","Innovative Medicines Initiative","UK Government’s Department of Health and Social Care","Medical Research Council","Kennedy Trust for Rheumatology Research","National Institute for Health Research (NIHR)","Kennedy Trust","Wellcome Trust","Ontario Genomics Institute","Wellcome Intermediate Fellowship"],"pagination":["1208-1219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8994591"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(7)"],"pubmed_abstract":["<h4>Background</h4>Natural and vaccine-induced immunity will play a key role in controlling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. SARS-CoV-2 variants have the potential to evade natural and vaccine-induced immunity.<h4>Methods</h4>In a longitudinal cohort study of healthcare workers (HCWs) in Oxfordshire, United Kingdom, we investigated the protection from symptomatic and asymptomatic polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection conferred by vaccination (Pfizer-BioNTech BNT162b2, Oxford-AstraZeneca ChAdOx1 nCOV-19) and prior infection (determined using anti-spike antibody status), using Poisson regression adjusted for age, sex, temporal changes in incidence and role. We estimated protection conferred after 1 versus 2 vaccinations and f"],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pubmed_title":["An Observational Cohort Study on the Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and B.1.1.7 Variant Infection in Healthcare Workers by Antibody and Vaccination Status."],"pmcid":["PMC8994591"],"funding_grant_id":["214560/Z/18/Z","NIHR200915","RP-PG-0514-20015","1097737","HDR-9006","115766","OGI-055","MR/N00065X/1","NF-SI-0508-10279","KENN202101","110110/Z/15/Z","NIHR200239"],"pubmed_authors":["Hatton E","Szczurkowska J","Sutton C","Wright S","Wheatley M","Barot S","Crawford-Jones D","Kirton R","Pickford H","James T","Prentice A","Thornton E","Clay H","Chau KK","Screaton G","Russell D","Abbott M","Vilca K","Perera V","Fragkouli E","Wharton V","Young S","Cogorno G","Oxford University Hospitals Staff Testing Group","Kotowska J","O'Sullivan O","Sanders A","Pikoula M","Westlake A","Mortimore E","Constantinides B","Hosseinzadeh S","Jones E","D'Amato G","Lashley N","Wozniak B","Moroney R","McGivern E","Ponting J","Wolna M","Toward R","Terry R","Shibu A","Sims E","Ross E","Odwin K","Pereira C","Cansdale L","Hatch SB","Jarratt Barnham I","Bastable J","Peto TEA","Economides G","Marsden BD","Conway-Jones R","Drummond B","Hill S","Savage K","de Toledo Z","Swann J","Yang-Turner F","Murugathasan A","Evans M","Layton M","Evans S","O'Donnell AM","Sharma I","Skelly D","Fadzillah M","Dunn L","Peck LJ","Sanderson N","Jarvis S","Cann K","Axten D","Jesuthasan G","Fields C","Somanathan A","Rylance-Knight L","Wolman R","Johnson T","Vaughan A","Callard H","Edwin C","Ramage S","Manji A","Phillips J","Mustoe E","Gates M","O'Donnell D","Crawley S","Thompson Z","Tamblyn M","Salvagno C","Stuart DI","Farache Trajano L","Innes G","Wilson J","Bodo N","Shimell K","Luciw M","Chmura M","Lucey M","Wilkins L","Tong H","Daly E","Weeks E","Cornall RJ","Jackson-Smith H","Khulusi B","Bland L","Cutteridge J","Mobbs A","Jeffery K","Kalimeris E","Walker AS","Volk D","Martins Ferreira L","Davies H","Bialek A","Jones EY","Pill G","Ritter TG","Cox V","Rodger G","Street TL","Lee K","Oakley S","Lee C","Hopkins S","Pether D","Thomas S","Conlon CP","Norris K","Lawson E","Curtis A","Shaw G","Mason S","Butler B","Caroll H","Ferreira C","Gentry J","Lumley SF","Holland L","Huda N","Justice A","Kavanagh J","Matthews PC","Pattrick F","Clarke J","Coward G","Holloway B","Virgo C","Antonucci N","Hoosdally S","Wareing S","Cox S","Rigler C","Madsen T","Ngoke G","Pouwels KB","Walker TM","Ravi K","Whitty A","J Neville M","Howarth A","Chand M","H Foord T","Butcher L","Mullins H","Hobden L","Tamblin-Hopper P","Eyre DW","Baby A","Tabirao M","Potter T","Welbourne A","Crook DW","Mighiu A","Grant O","Ward J","Cordy S","Christott T","Doherty G","Nezhentsev A","Shabir Z","W Fowler P","Millard R","Dobson J","Karpe F","Ebner D","Stoesser NE","Abhari R","Chohan R","Brown J","Lyden S","Warren F","Fuchs H","Cameron S","Oliver J","Warren L","Brown R","Perry S"],"additional_accession":[]},"is_claimable":false,"name":"An Observational Cohort Study on the Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and B.1.1.7 Variant Infection in Healthcare Workers by Antibody and Vaccination Status.","description":"<h4>Background</h4>Natural and vaccine-induced immunity will play a key role in controlling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. SARS-CoV-2 variants have the potential to evade natural and vaccine-induced immunity.<h4>Methods</h4>In a longitudinal cohort study of healthcare workers (HCWs) in Oxfordshire, United Kingdom, we investigated the protection from symptomatic and asymptomatic polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection conferred by vaccination (Pfizer-BioNTech BNT162b2, Oxford-AstraZeneca ChAdOx1 nCOV-19) and prior infection (determined using anti-spike antibody status), using Poisson regression adjusted for age, sex, temporal changes in incidence and role. We estimated protection conferred after 1 versus 2 vaccinations and f","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-05-29T21:52:31.313Z","creation":"2025-05-29T21:52:31.313Z"},"accession":"S-EPMC8994591","cross_references":{"pubmed":["34216472"],"doi":["10.1093/cid/ciab608"]}}