biostudies-literatureBos FMEuropean Research Councilrob giel research centerZonMw12https://www.ebi.ac.uk/biostudies/studies/S-EPMC8994809biostudies-literatureUnknown10(1)<h4>Background</h4>In bipolar disorder treatment, accurate episode prediction is paramount but remains difficult. A novel idiographic approach to prediction is to monitor generic early warning signals (EWS), which may manifest in symptom dynamics. EWS could thus form personalized alerts in clinical care. The present study investigated whether EWS can anticipate manic and depressive transitions in individual patients with bipolar disorder.<h4>Methods</h4>Twenty bipolar type I/II patients (with ≥ 2 episodes in the previous year) participated in ecological momentary assessment (EMA), completing five questionnaires a day for four months (Mean = 491 observations per person). Transitions were determined by weekly completed questionnaires on depressive (Quick Inventory for Depressive SymptomatoloInternational journal of bipolar disordersAnticipating manic and depressive transitions in patients with bipolar disorder using early warning signals.PMC8994809681466451001029Bos FMGeorge SVSnippe ESchreuder MJHaarman BCMDoornbos Bvan der Krieke LWichers MBruggeman RfalseAnticipating manic and depressive transitions in patients with bipolar disorder using early warning signals.<h4>Background</h4>In bipolar disorder treatment, accurate episode prediction is paramount but remains difficult. A novel idiographic approach to prediction is to monitor generic early warning signals (EWS), which may manifest in symptom dynamics. EWS could thus form personalized alerts in clinical care. The present study investigated whether EWS can anticipate manic and depressive transitions in individual patients with bipolar disorder.<h4>Methods</h4>Twenty bipolar type I/II patients (with ≥ 2 episodes in the previous year) participated in ecological momentary assessment (EMA), completing five questionnaires a day for four months (Mean = 491 observations per person). Transitions were determined by weekly completed questionnaires on depressive (Quick Inventory for Depressive Symptomatolo2022-01-01T00:00:00Z2022 Apr2025-04-26T18:36:57.793Z2025-04-06T15:49:08.204ZS-EPMC89948093539707610.1186/s40345-022-00258-4