{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(4)"],"submitter":["Harp C"],"funding":["Genentech"],"pubmed_abstract":["<h4>Objective</h4>To develop an age-adjustment model for neurofilament light chain (NfL), an emerging injury marker in patients with a range of neurologic conditions including multiple sclerosis (MS).<h4>Methods</h4>Serum and plasma samples were collected from a healthy donor (HD) cohort of 118 individuals aged 24 to 66 years, 90 patients with relapsing MS (RMS) and 22 patients with progressive MS (PMS). Serum and plasma samples were assessed for NfL using the SIMOA assay (Quanterix NfL Advantage Kit™). A log-linear model was used to evaluate the relationship between NfL and age and to calculate age-adjusted NfL levels.<h4>Results</h4>Higher serum and plasma NfL levels were significantly associated with increasing HD age. Log-transformation of blood NfL levels reduced heteroscedasticity an"],"journal":["Annals of clinical and translational neurology"],"pagination":["444-453"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8994974"],"repository":["biostudies-literature"],"pubmed_title":["Development of an age-adjusted model for blood neurofilament light chain."],"pmcid":["PMC8994974"],"pubmed_authors":["Hendricks R","Harp C","Benkert P","Herman A","Kuhle J","Leppert D","Schaedelin S","von Budingen HC","Jia X","Thanei GA"],"additional_accession":[]},"is_claimable":false,"name":"Development of an age-adjusted model for blood neurofilament light chain.","description":"<h4>Objective</h4>To develop an age-adjustment model for neurofilament light chain (NfL), an emerging injury marker in patients with a range of neurologic conditions including multiple sclerosis (MS).<h4>Methods</h4>Serum and plasma samples were collected from a healthy donor (HD) cohort of 118 individuals aged 24 to 66 years, 90 patients with relapsing MS (RMS) and 22 patients with progressive MS (PMS). Serum and plasma samples were assessed for NfL using the SIMOA assay (Quanterix NfL Advantage Kit™). A log-linear model was used to evaluate the relationship between NfL and age and to calculate age-adjusted NfL levels.<h4>Results</h4>Higher serum and plasma NfL levels were significantly associated with increasing HD age. Log-transformation of blood NfL levels reduced heteroscedasticity an","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-19T00:44:15.802Z","creation":"2025-04-07T11:46:07.197Z"},"accession":"S-EPMC8994974","cross_references":{"pubmed":["35229997"],"doi":["10.1002/acn3.51524"]}}