biostudies-literatureSchilaty NDNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNICHD NIH HHSNIAMS NIH HHS515-528https://www.ebi.ac.uk/biostudies/studies/S-EPMC8994990biostudies-literatureUnknown9(4)<h4>Objective</h4>Multiple Sclerosis (MS) is often accompanied by myelopathy, which may be associated with progressive worsening. A specific finding of MS-associated myelopathy is McArdle sign, wherein neck flexion is associated with prominent increased limb weakness relative to that detected with neck extension. In this study, we characterized neuromotor control properties of finger extensors in association with the McArdle sign.<h4>Methods</h4>A custom-built device was utilized to monitor torque production of the wrist extensors with simultaneous recording of surface electromyography of the extensor digitorum. The electromyography was decomposed and analyzed via both linear and nominal regressions.<h4>Results</h4>Linear regressions demonstrated a strong difference between groups for MS fAnnals of clinical and translational neurologyNeuromotor control associates with muscle weakness observed with McArdle sign of multiple sclerosis.PMC8994990L30AR070273K12 HD065987L30 AR070273Weinshenker BGNasr ZSavoldi FSchilaty NDfalseNeuromotor control associates with muscle weakness observed with McArdle sign of multiple sclerosis.<h4>Objective</h4>Multiple Sclerosis (MS) is often accompanied by myelopathy, which may be associated with progressive worsening. A specific finding of MS-associated myelopathy is McArdle sign, wherein neck flexion is associated with prominent increased limb weakness relative to that detected with neck extension. In this study, we characterized neuromotor control properties of finger extensors in association with the McArdle sign.<h4>Methods</h4>A custom-built device was utilized to monitor torque production of the wrist extensors with simultaneous recording of surface electromyography of the extensor digitorum. The electromyography was decomposed and analyzed via both linear and nominal regressions.<h4>Results</h4>Linear regressions demonstrated a strong difference between groups for MS f2022-01-01T00:00:00Z2022 Apr2025-04-19T00:42:33.948Z2025-04-07T11:43:33.645ZS-EPMC89949903528911010.1002/acn3.51526